Abnormal expression of CD54 in mixed reactions of mononuclear cells from hyper-IgE syndrome patients

Memórias do Instituto Oswaldo Cruz
Adriano M MartínezPablo J Patiño

Abstract

Hyper-IgE syndrome (HIES) is a rare multisystem disorder characterized by increased susceptibility to infections associated with heterogeneous immunologic and non-immunologic abnormalities. Most patients consistently exhibit defective antigen-induced-T cell activation, that could be partly due to altered costimulation involving accessory molecules; however, the expression of these molecules has never been documented in HIES. Therefore, we investigated the expression of CD11a, CD28, CD40, CD54, CD80, CD86, and CD154 in peripheral blood mononuclear cells from six patients and six healthy controls by flow cytometry after autologous and mixed allogeneic reactions. Only the allogeneic stimuli induced significant proliferative responses and interleukin 2 and interferon gamma production in both groups. Most accessory, molecules showed similar expression between patients and controls with the exception of CD54, being expressed at lower levels in HIES patients regardless of the type of stimulus used. Decreased expression of CD54 could partly explain the deficient T cell activation to specific recall antigens in HIES patients, and might be responsible for their higher susceptibility to infections with defined types of microorganisms.

References

Jun 1, 1991·Current Opinion in Immunology·G A van SeventerS Shaw
May 1, 1990·The Journal of Clinical Investigation·D VercelliR S Geha
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J E SlighA L Beaudet
Jan 1, 1996·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·A van de Stolpe, P T van der Saag
Jan 1, 1997·Annual Review of Immunology·U BoehmJ C Howard
Dec 22, 1998·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·M F RodríguezD García de Olarte
Feb 9, 1999·The Journal of Allergy and Clinical Immunology·O GarraudT B Nutman
Mar 4, 1999·The New England Journal of Medicine·B GrimbacherJ M Puck
Aug 12, 1999·American Journal of Human Genetics·B GrimbacherJ M Puck
Oct 3, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·L VargasD G de Olarte
Dec 30, 1999·Journal of Leukocyte Biology·K A Roebuck, A Finnegan
Mar 13, 2001·Annual Review of Immunology·S K BromleyM L Dustin
Mar 28, 2001·Clinical Reviews in Allergy & Immunology·R H Buckley
Jun 21, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·J ChehimiK E Sullivan
Jul 11, 2001·Immunologic Research·D W Ballard
Feb 28, 2002·Annual Review of Immunology·Beatriz M Carreno, Mary Collins
Jun 1, 2002·Science·Andrew L Singer, Gary A Koretzky

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Citations

Sep 1, 2005·Journal of Clinical Immunology·E D RennerS Rothenfusser
Mar 23, 2015·Allergologia et immunopathologia·S Gutierrez-HincapiéC M Trujillo-Vargas
Nov 1, 2005·Expert Review of Clinical Immunology·Alexandra F Freeman, Steven M Holland

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