Abnormal expression of ephrin-A5 affects brain development of congenital hypothyroidism rats

Neuroreport
Guihai SuoYoujia Wu

Abstract

EphA5 and its ligand ephrin-A5 interaction can trigger synaptogenesis during early hippocampus development. We have previously reported that abnormal EphA5 expression can result in synaptogenesis disorder in congenital hypothyroidism (CH) rats. To better understand its precise molecular mechanism, we further analyzed the characteristics of ephrin-A5 expression in the hippocampus of CH rats. Our study revealed that ephrin-A5 expression was downregulated by thyroid hormone deficiency in the developing hippocampus and hippocampal neurons in rats. Thyroxine treatment for hypothyroid hippocampus and triiodothyronine treatment for hypothyroid hippocampal neurons significantly improved ephrin-A5 expression but could not restore its expression to control levels. Hypothyroid hippocampal neurons in-vitro showed synaptogenesis disorder characterized by a reduction in the number and length of neurites. Furthermore, the synaptogenesis-associated molecular expressions of NMDAR-1 (NR1), PSD95 and CaMKII were all downregulated correspondingly. These results suggest that ephrin-A5 expression may be decreased in CH, and abnormal activation of ephrin-A5/EphA5 signaling affects synaptogenesis during brain development. Such findings provide an impo...Continue Reading

References

Feb 7, 2001·Current Opinion in Neurobiology·R P KesnerG V Wallenstein
Mar 21, 2001·Nature Reviews. Neuroscience·D G Wilkinson
Sep 15, 2001·Nature·C A Cowan, M Henkemeyer
Dec 14, 2002·The International Journal of Biochemistry & Cell Biology·Juha-Pekka Himanen, Dimitar B Nikolov
May 22, 2003·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Joanne F Rovet
Dec 4, 2003·Thyroid : Official Journal of the American Thyroid Association·Grant W AndersonSidney A Jones
Apr 27, 2004·Nature Neuroscience·Juha-Pekka HimanenDimitar B Nikolov
Sep 15, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jacques Huot
Mar 31, 2005·Biochemical and Biophysical Research Communications·Kazuyo KamitoriShinichi Kohsaka
Apr 26, 2005·Neuron·Christopher W CowanMichael E Greenberg
Jun 2, 2005·Nature Reviews. Molecular Cell Biology·Elena B Pasquale
Nov 23, 2007·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Osama M AhmedR G Ahmed
Mar 21, 2008·Current Opinion in Cell Biology·Anna Merlos-Suárez, Eduard Batlle
Nov 13, 2008·Developmental Neurobiology·Margaret A CooperRenping Zhou
Mar 28, 2009·The Journal of Comparative Neurology·Margaret A CooperRenping Zhou
Feb 25, 2010·Nature Reviews. Cancer·Elena B Pasquale
Aug 21, 2013·Proceedings of the National Academy of Sciences of the United States of America·Kai XuDimitar B Nikolov
Dec 9, 2014·Cell Adhesion & Migration·Francois FagottoNazanin Rohani
Dec 9, 2014·Cell Adhesion & Migration·J LaussuA Davy
Jun 26, 2015·Journal of Molecular Neuroscience : MN·Youjia WuJinlong Shi
Jan 23, 2016·Nature Reviews. Molecular Cell Biology·Artur Kania, Rüdiger Klein
Mar 5, 2016·Frontiers in Physiology·Guilherme M XavierMartyn T Cobourne
Apr 20, 2016·F1000Research·Karina S Cramer, Ilona J Miko

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Citations

Apr 20, 2019·Frontiers in Endocrinology·Barbara K Stepien, Wieland B Huttner
Apr 30, 2021·Frontiers in Cell and Developmental Biology·Chunhai ChenLei Zhang

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Methods Mentioned

BETA
PCR
fluorescence microscopy

Software Mentioned

SPSS
Gene
Rotor
PDQuest

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