Abnormal expression of menin predicts the pathogenesis and poor prognosis of adult gliomas.

Cancer Gene Therapy
Zhan-Feng WangGuang-Hui Jin

Abstract

Several brain tumors is closely related to the disorder of chromatin histone modification, whereas the epigenetic mechanisms of the incidence of highly malignant adult glioma is not yet deeply studied. Deletion or mutation of the MEN1 gene, which encodes the epigenetic regulator menin, specifically induces poorly differentiated neuroendocrine tumors; however, the biological and clinical importance of MEN1 in the nervous system remains poorly understood. Menin expression was robustly activated in 44.4% of adult gliomas. Abnormally high expression of menin was closely related to a shorter median survival time of 20 months, a larger tumor volume and a higher percentage of Ki67 staining. Interestingly, menin expression was also activated in the cytoplasm of tumor cells (38.8%) and was also closely related to the poor prognosis of patients with glioma. Importantly, in a screening of 96 types of small-molecule targeted histone modification regulators, menin inhibitors were found to significantly block the proliferation of adult glioma cells. Our findings confirm that menin is a potential biomarker of poor prognosis in adult gliomas, independent of the WHO grade. Targeting menin may effectively inhibit certain gliomas, and this inform...Continue Reading

References

Feb 7, 2001·Proceedings of the National Academy of Sciences of the United States of America·J S CrabtreeF S Collins
Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Jul 10, 2007·Acta Neuropathologica·David N LouisPaul Kleihues
Mar 14, 2008·The New England Journal of Medicine·Manel Esteller
Aug 5, 2009·Molecular and Cellular Biology·Yanan CaoGuang Ning
Jul 12, 2011·Cancer Cell·Kathrin M BerntScott A Armstrong
Jul 20, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kuen-Tyng LinYuh-Shan Jou
Oct 3, 2012·The Journal of Biological Chemistry·Yuan WuGuang-Hui Jin
Apr 13, 2013·Cell Death & Disease·Y-J YangE-J Cho
Jul 16, 2013·Trends in Biochemical Sciences·Smita MatkarXianxin Hua
Oct 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·Bin XuGuang-Hui Jin
Jun 7, 2014·Pharmacological Reports : PR·Xiaofeng ShenFuzhou Wang
Mar 31, 2015·Nature Medicine·Rohit MalikArul M Chinnaiyan
Jun 11, 2015·The New England Journal of Medicine·Jeanette E Eckel-PassowRobert B Jenkins
Mar 8, 2016·Handbook of Clinical Neurology·Kenta MasuiGuido Reifenberger
Dec 30, 2016·Nature Reviews. Clinical Oncology·Guido ReifenbergerMichael Weller
Mar 7, 2017·Nature Medicine·Faizaan MohammadKristian Helin
Mar 9, 2017·Cell Reports·Koen M A DreijerinkMyles Brown
Dec 14, 2017·Molecular Cancer Research : MCR·Peng ZhangFrank A Sinicrope

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection
acetylation
PCR
GTPase

Software Mentioned

GraphPad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cancer Genetics and Cytogenetics
Marco F ManzoniPaola Carrera
The Journal of Clinical Endocrinology and Metabolism
B MayrA von zur Mühlen
Nature Reviews. Cancer
Nicola McCarthy
© 2021 Meta ULC. All rights reserved