Abnormal expression of miR-1 in breast carcinoma as a potent prognostic factor

Cancer Science
Hiroyuki MinemuraTakashi Suzuki

Abstract

Metastatic breast cancer remains a highly lethal disease, and it is very important to evaluate the biomarkers associated with the distant metastasis. MicroRNA (miRNA) are small non-protein coding RNA that regulate various cellular functions. Recent investigations have demonstrated the importance of some miRNA in breast cancer, but the significance of the great majority of miRNA remains largely unclear in breast cancer metastasis. Therefore, in this study, we first examined expression profiles of miRNA in stage IV breast carcinoma tissues, comparing stage I-III cases by miRNA PCR array, and identified miR-1 as the miRNA which was the most associated with the distant metastasis. However, miR-1 has not yet been examined in breast carcinoma tissue, and its significance remains unknown. Therefore, we further examined miR-1 expression in breast carcinoma using in situ hybridization (ISH). miR-1 was localized in carcinoma cells in 20% of breast carcinoma cases, but it was negligible in non-neoplastic mammary glands or stroma. miR-1 ISH status was significantly associated with stage, pathological T factor, lymph node metastasis, distant metastasis, histological grade, estrogen receptor, progesterone receptor and Ki-67 in breast carcino...Continue Reading

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Citations

Feb 2, 2019·Molecular Biology Reports·Huseyin AkbulutMahmut Muslumanoglu
Jan 7, 2020·Oncotarget·Eleni ZografosMeletios-Athanasios Dimopoulos
May 8, 2020·Molecular Medicine Reports·Jing PengJinsong Lu
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Methods Mentioned

BETA
PCR
dissection
chromosomal aberration

Software Mentioned

miScript PCR Array
JMP

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