PMID: 7535733Apr 1, 1995Paper

Abnormal expression of the E2 component of the pyruvate dehydrogenase complex on the luminal surface of biliary epithelium occurs before major histocompatibility complex class II and BB1/B7 expression

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
K TsuneyamaM E Gershwin

Abstract

Primary biliary cirrhosis (PBC) is a chronic autoimmune liver disease characterized histologically by nonsuppurative destructive cholangitis. Sera from patients with PBC react with a series of intramitochondrial enzymes with the immunodominant response directed against the E2 component of the pyruvate dehydrogenase complex (PDC-E2). Recently, using tissue sections of late-stage PBC, we showed that there is increased expression in biliary epithelial cells of patients with PDC-E2 or a molecule cross-reactive with PDC-E2. Previous work has shown that biliary epithelial cells of patients with PBC express an increased amount of class II. To address the sequence of events in the evolution of PBC, we have focused our attention in this study on early biliary epithelial lesions. In particular, we have studied the liver of 22 female patients with PBC that was diagnosed as either stage I or stage II using both a mouse monoclonal antibody that has reactivity similar to human autoantibodies as well as a human Fab combinatorial prepared from the lymph node of a PBC patient. Tissues were simultaneously stained using antibodies to PDC-E2, class II, and BB1/B7. As a positive control, tissues from late-stage PBC were studied concurrently. By det...Continue Reading

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Citations

Mar 21, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A MattaliaM E Gershwin
Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J Neuberger, R Thomson
Jul 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G HrehaJ M Vierling
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May 29, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S ShimodaH Ishibashi
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Nov 2, 2013·World Journal of Hepatology·Ourania SfakianakiElias Kouroumalis
Apr 30, 2020·Journal of Leukocyte Biology·Vincenzo RoncaPietro Invernizzi

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