Abnormal expression of the programmed cell death 5 gene in acute and chronic myeloid leukemia

Leukemia Research
Guo-Rui RuanYan-Rong Liu

Abstract

To clarify whether expression of the programmed cell death 5 (PDCD5) gene in leukemic cells is abnormal, real-time quantitative reverse transcription polymerase chain reaction (RQ-RT-PCR) was used to examine its expression in marrow cells from leukemia patients. We found lower PDCD5 in both AML and CML marrow cells than in normal donor marrow cells. A negative correlation was found between relative levels of PDCD5 and BCR/ABL expression in all CML patients and in CML patients in the advanced phase. Treatment with the ABL tyrosine kinase inhibitor Imatinib mesylate increased PDCD5 expression in K562 and MEG-01 cells. These findings suggest that abnormal expression of PDCD5 in leukemia may be involved in the pathomechanism of AML and CML.

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Citations

May 1, 2007·Apoptosis : an International Journal on Programmed Cell Death·Ning WangChu-Jie Bai
Apr 11, 2008·Apoptosis : an International Journal on Programmed Cell Death·Guo-Rui RuanXiao-Jun Huang
Jun 25, 2009·Apoptosis : an International Journal on Programmed Cell Death·Min XieGuo-Rui Ruan
Mar 30, 2010·Apoptosis : an International Journal on Programmed Cell Death·Changbao ChenYingyu Chen
Aug 24, 2012·Apoptosis : an International Journal on Programmed Cell Death·Lanjun XuYingyu Chen
Sep 1, 2011·Chinese Journal of Cancer Research = Chung-kuo Yen Cheng Yen Chiu·Yue WangQing-Yun Zhang
Nov 14, 2013·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Lanlan WangLu Wang
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Jul 31, 2016·Apoptosis : an International Journal on Programmed Cell Death·Jiao ZhouGuo-Rui Ruan
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