Abnormal expression of transcription factor activator protein-2α in pathologic placentas.

Human Pathology
Rachel M SheridanStuart Handwerger

Abstract

Recent studies from our laboratory have indicated that the transcription factor activator protein-2α plays a critical role in the differentiation of human villous cytotrophoblast cells to syncytiotrophoblast cells. However, little is known about the expression of activator protein-2α in placentas from pathologic pregnancies. This study compares the expression of activator protein-2α in placentas from high-risk pregnancies to gestational age-matched controls. Paracentral sections from grossly unremarkable areas of 10 placentas from each group of pregnancies complicated by mild preeclampsia, severe preeclampsia, diabetes mellitus, chronic hypertension, and fetal growth restriction and 10 control cases of placentas from normal pregnancies matched for gestational age were double immunostained for activator protein-2α and E-cadherin. The total numbers of cytotrophoblast cells and syncytiotrophoblast nuclei and the numbers of activator protein-2α-positive and activator protein-2α-negative nuclei in both of these cell types were counted by 2 pathologists blinded to disease status, in 10 representative×40 high-power fields for each placenta. Abnormal placental maturation in most of pathologic pregnancies was evidenced by a 1.5- to 1.7-...Continue Reading

References

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Citations

May 1, 2013·Archives of Pathology & Laboratory Medicine·Jerzy Stanek
Feb 5, 2015·Endocrinology·Cherie A KesslerStuart Handwerger
Sep 22, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Arthur ColsonFrédéric Debiève
Jun 3, 2020·Proceedings of the National Academy of Sciences of the United States of America·Gudrun MeinhardtMartin Knöfler

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