PMID: 19928018Nov 26, 2009Paper

Abnormal fMRI activation pattern during story listening in individuals with Down syndrome

American Journal on Intellectual and Developmental Disabilities
Elizabeth A Reynolds LosinJoseph D Pinter

Abstract

Down syndrome is characterized by disproportionately severe impairments of speech and language, yet little is known about the neural underpinnings of these deficits. We compared fMRI activation patterns during passive story listening in 9 young adults with Down syndrome and 9 approximately age-matched, typically developing controls. The typically developing group exhibited greater activation than did the Down syndrome group in classical receptive language areas (superior and middle temporal gyri) for forward > backward speech; the Down syndrome group exhibited greater activation in cingulate gyrus, superior and inferior parietal lobules, and precuneus for both forward speech > rest and backward speech > rest. The Down syndrome group showed almost no difference in activation patterns between the language (forward speech) and nonlanguage (backward speech) conditions.

References

Mar 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M B SchapiroS I Rapoport
Jun 1, 1984·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·R TannockJ Oliver
Nov 1, 1994·Brain and Cognition·D ElliottR Chua
May 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·N P AzariB Horwitz
May 1, 1997·Journal of Experimental Child Psychology·Y M CycowiczJ G Snodgrass
Apr 1, 1997·The British Journal of Psychiatry : the Journal of Mental Science·S FrangouR M Murray
Oct 27, 1997·The American Journal of Psychiatry·S FrangouG Pearlson
Aug 17, 1999·Brain and Language·M Heath, D Elliott
Oct 2, 2001·The American Journal of Psychiatry·J D PinterA L Reiss
Nov 28, 2001·Down's Syndrome, Research and Practice : the Journal of the Sarah Duffen Centre·C Stoel-Gammon
Oct 17, 2002·Journal of Speech, Language, and Hearing Research : JSLHR·Robin S ChapmanDoris J Kistler
Dec 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·Michael D GreiciusVinod Menon
Feb 20, 2003·Brain and Language·Timothy N WelshDominic A Simon
Apr 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Michael D GreiciusVinod Menon
Oct 27, 2004·NeuroImage·Stephen M SmithPaul M Matthews
Nov 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Eiman AzimAllan L Reiss
Nov 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Teresa FarroniGergely Csibra
Jan 7, 2006·MMWR. Morbidity and Mortality Weekly Report·UNKNOWN Centers for Disease Control and Prevention (CDC)
Mar 15, 2006·Brain Research Reviews·Martin SarterRouba Kozak
Apr 28, 2006·Pediatric Neurology·Zsolt LengyelEva Oláh
Dec 1, 2006·Trends in Cognitive Sciences·Masud Husain, Parashkev Nachev
Mar 3, 2007·The American Journal of Psychiatry·Abigail G GarrityVince D Calhoun
Sep 11, 2007·International Journal of Audiology·Scott K HollandAnna W Byars
Oct 3, 2007·Mental Retardation and Developmental Disabilities Research Reviews·Leonard AbbedutoFrances A Conners
Jan 15, 2008·Journal of Neuroscience Methods·Lucina Q UddinMichael P Milham
Apr 11, 2008·Cerebral Cortex·A Di MartinoM P Milham
Apr 22, 2009·AJR. American Journal of Roentgenology·Jennifer VannestScott K Holland
Sep 30, 2009·American Journal of Medical Genetics. Part a·Brian G SkotkoUNKNOWN Down Syndrome Diagnosis Study Group

❮ Previous
Next ❯

Citations

Mar 31, 2015·American Journal of Medical Genetics. Part a·Elizabeth I AdeyemiNancy Raitano Lee
May 1, 2013·Wiley Interdisciplinary Reviews. Cognitive Science·Jamie O Edgin
Oct 7, 2015·Frontiers in Behavioral Neuroscience·Jamie O EdginAnnette Karmiloff-Smith
Nov 2, 2013·NeuroImage. Clinical·Jeffrey S AndersonJulie R Korenberg
Jul 2, 2015·Journal of Neurodevelopmental Disorders·Jeffrey S AndersonJulie R Korenberg
Sep 13, 2011·American Journal on Intellectual and Developmental Disabilities·Lisa M JacolaMark B Schapiro
May 22, 2019·Insights Into Imaging·Marta RodriguesAna Filipa Geraldo
May 13, 2020·Frontiers in Human Neuroscience·Maria Carbó-CarretéJoan Guàrdia-Olmos

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.