Abnormal food timing and predisposition to weight gain: Role of barrier dysfunction and microbiota.

Translational Research : the Journal of Laboratory and Clinical Medicine
Faraz BishehsariAli Keshavarzian

Abstract

Obesity has become a common rising health care problem, especially in "modern" societies. Obesity is considered a low-grade systemic inflammation, partly linked to leaky gut. Circadian rhythm disruption, a common habit in modern life, has been reported to cause gut barrier impairment. Abnormal time of eating, defined by eating close to or during rest time, is shown to cause circadian rhythm disruption. Here, using a non-obesogenic diet, we found that abnormal feeding time facilitated weight gain and induced metabolic dysregulation in mice. The effect of abnormal time of eating was associated with increased gut permeability, estimated by sucralose and/or lactulose ratio and disrupted intestinal barrier marker. Analysis of gut microbiota and their metabolites, as important regulators of barrier homeostasis, revealed that abnormal food timing reduced relative abundance of butyrate-producing bacteria, and the colonic butyrate level. Overall, our data supported that dysbiosis was characterized by increased intestinal permeability and decreased beneficial barrier butyrate-producing bacteria and/or metabolite to mechanistically link the time of eating to obesity. This data provides basis for noninvasive microbial-targeted intervention...Continue Reading

References

Aug 10, 2000·Gastroenterology·L A Scheving
Apr 23, 2005·Science·Fred W TurekJoseph Bass
Oct 7, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Paola BrunDiego Martines
Dec 15, 2006·Nature·Steven E KahnKristina M Utzschneider
Apr 26, 2007·Diabetes·Patrice D CaniRémy Burcelin
Apr 13, 2010·Nature Methods·J Gregory CaporasoRob Knight
Oct 13, 2010·Proceedings of the National Academy of Sciences of the United States of America·Laura K FonkenRandy J Nelson
Mar 9, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·S de KortA A M Masclee
Apr 10, 2012·Annual Review of Neuroscience·Jennifer A MohawkJoseph S Takahashi
Aug 11, 2012·Progress in Brain Research·Dirk Jan StenversAndries Kalsbeek
Oct 23, 2012·Cell Host & Microbe·Ivaylo I Ivanov, Kenya Honda
Jan 10, 2014·Scandinavian Journal of Work, Environment & Health·Massimo BracciLory Santarelli
May 23, 2014·PloS One·Robin M VoigtAli Keshavarzian
Feb 5, 2015·Cell Metabolism·Brian W ParksAldons J Lusis
Jul 1, 2015·Diabetes & Metabolism Journal·Kyu Yeon Hur, Myung-Shik Lee
Feb 5, 2016·Alcoholism, Clinical and Experimental Research·Robin M VoigtAli Keshavarzian
May 21, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Garth R SwansonAli Keshavarzian
Aug 3, 2016·Gastroenterology·Faraz BishehsariAli Keshavarzian
Dec 3, 2016·Cell·Christoph A ThaissEran Elinav
Feb 10, 2017·Nature·Gökhan S Hotamisligil
Jun 6, 2017·Current Biology : CB·Sophie M T WehrensJonathan D Johnston
Sep 29, 2017·Tissue Barriers·Tatiana TakiishiNiels Olsen Saraiva Câmara
May 1, 2018·Frontiers in Microbiology·Jessica A DeaverMichal Toborek
Jun 24, 2018·Gut·Patrice D Cani
Dec 15, 2018·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·S Moossavi, F Bishehsari
Apr 21, 2019·International Journal of Molecular Sciences·Katharina Kessler, Olga Pivovarova-Ramich
Oct 12, 2019·Science·Faraz Bishehsari, Ali Keshavarzian
Nov 7, 2019·Cellular and Molecular Gastroenterology and Hepatology·Faraz BishehsariKhashayarsha Khazaie
May 22, 2020·Chemico-biological Interactions·Faraz BishehsariAli Keshavarzian
Aug 28, 2020·Frontiers in Oncology·Faraz BishehsariYue Zhang
Oct 28, 2020·Nature Reviews. Endocrinology·Faraz BishehsariAli Keshavarzian

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Citations

Aug 7, 2021·Eating and Weight Disorders : EWD·Muhammad AlsayidFaraz Bishehsari

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