Abnormal galactosylation of immunoglobulin G in cerebrospinal fluid of multiple sclerosis patients

Multiple Sclerosis : Clinical and Laboratory Research
Yann DeckerKlaus Fassbender

Abstract

Glycosylation alterations have been associated with the development of several human diseases and their animal models, including multiple sclerosis. We aimed to determine whether immunoglobulin G galactosylation might be changed in multiple sclerosis. Immunoglobulin G was isolated from serum and cerebrospinal fluid of patients with multiple sclerosis or viral meningitis and control patients without history of inflammatory or autoimmune disease. A lectin-based assay was used to investigate potential galactosylation modifications of immunoglobulin G. Galactosylation of immunoglobulin G isolated from cerebrospinal fluid of control patients was found to be age- and gender-dependent. In addition, immunoglobulin G galactosylation was significantly altered in cerebrospinal fluid but not in serum of multiple sclerosis patients. Furthermore, this modification was correlated with an active progression of multiple sclerosis. Finally, the loss of galactosyl moieties was not simply associated with inflammation as no such change was detected in viral meningitis patients characterized by brain inflammation.

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Citations

Dec 3, 2016·Expert Review of Molecular Diagnostics·Matteo GastaldiDiego Franciotta
Oct 27, 2017·Science Signaling·Siobhan Ni ChoileainAnne L Astier
May 5, 2021·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Peter G E KennedyXiaoli Yu
Nov 5, 2021·Frontiers in Immunology·Kristina Zlatina, Sebastian P Galuska
Nov 28, 2021·Pharmaceuticals·Roberto De Masi, Stefania Orlando
Jan 8, 2022·The Journal of Applied Laboratory Medicine·Rebecca S Treger, Susan L Fink

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Methods Mentioned

BETA
glycosylation
electrophoresis
Protein Assay
ELISA

Software Mentioned

Statistical Package for the Social Sciences

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