Abnormal gastroesophageal flap valve is highly associated with gastroesophageal reflux disease among subjects undergoing routine endoscopy in Taiwan

Journal of Gastroenterology and Hepatology
Bor-Ru LinTeh-Hong Wang

Abstract

Gastroesophageal flap valve (GEFV) grade predicts severe gastroesophageal reflux disease in Caucasians, but its role in other populations is unclear. This study evaluated the significance of endoscopic grading of the GEFV in Taiwanese subjects. Five hundred and six consecutive patients undergoing routine check-ups at the National Taiwan University Hospital were enrolled. Symptoms of upper gastrointestinal disease and endoscopic severity of esophageal mucosal injury were correlated to GEFV grades according to the Hill classification. The frequency of abnormal valves (Hill grades III or IV) was 27.3%. Of these, 42.7% had erosive esophagitis (EE). The majority of patients with EE were classified as Los Angeles grades A and B (79.7 and 16.9%, respectively). The prevalence of EE, hiatal hernia and, to a lesser degree, non-erosive reflux disease, increased with altered GEFV. Patients with abnormal valves were younger and more likely to be male, overweight, and to have atypical and extraesophageal symptoms. Taiwanese patients with abnormal GEFVs share similar characteristics and risk factors with the patients who have EE. Endoscopic grading of the GEFV is highly associated with GERD, and in particular EE, in subjects undergoing routin...Continue Reading

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Citations

Mar 6, 2008·Journal of Gastroenterology and Hepatology·Chien-Chung LiaoChristopher J Gostout
Feb 22, 2008·Journal of Gastroenterology and Hepatology·Gwang Ha KimDae Hwan Kang
Jun 4, 2014·Auris, Nasus, Larynx·Mustafa KaplanYusuf Yazgan
Apr 26, 2015·The Kaohsiung Journal of Medical Sciences·Wen-Hung HsuChao-Hung Kuo
Jun 12, 2009·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·B OdemişO Yüksel
Sep 13, 2008·The Korean Journal of Internal Medicine·Ji Hyun KimYoung-Tae Bak
Apr 4, 2009·Current Opinion in Gastroenterology·Syed-Mohammed JafriGeorge Triadafilopoulos
Aug 6, 2008·World Journal of Gastroenterology : WJG·Yung-Chih LaiJun-Chen Lin
Nov 7, 2017·European Surgery : ACA : Acta Chirurgica Austriaca·Michael WeitzendorferOliver Owen Koch
Sep 25, 2020·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Jun Young KimPoong-Lyul Rhee

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