Abnormal GERD parameters on ambulatory pH monitoring predict therapeutic success in noncardiac chest pain.

The American Journal of Gastroenterology
Vladimir M KushnirC Prakash Gyawali

Abstract

The value of gastroesophageal reflux disease (GERD) indicators (acid exposure time (AET), symptom association probability (SAP), and symptom index (SI)) in predicting therapeutic success in noncardiac chest pain (NCCP) has not been systematically evaluated in outcome studies. We retrospectively identified 98 subjects with NCCP (age 51.8+/-1.2 years, 75 women, mean duration of symptoms 7.3+/-0.4 years) who underwent pH monitoring off antireflux therapy. Distal esophageal AET (abnormal if > or = 4.0%), SAP (measured as Ghillibert probability estimate, abnormal if P<0.05), and SI (abnormal if > or = 50%) were calculated; symptom severity and change after therapy were assessed on a 10-point Likert scale. Subjects were interviewed 2.8+/-0.9 years after the pH study to determine the degree of symptom change (high-degree response (HDR), with definite, sustained symptom improvement) after antireflux therapy. Regression analysis was used to determine the independent predictors of HDR. GERD indicators were present in 61 subjects (62.2%); 52 subjects (53.1%) had abnormal AET, 26 (26.5%) had positive SAP, and 25 (25.5%) had positive SI. With therapy, mean symptom scores improved from 6.3+/-0.3 at the time of the pH study to 2.9+/-0.3 at th...Continue Reading

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Citations

Nov 4, 2010·Digestive Diseases and Sciences·Vladimir M KushnirC Prakash Gyawali
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