Abstract
Glomerular filtration rate (GFR) and tubular function were measured by means of the lithium clearance technique in 14 patients with renovascular hypertension (RVH) and eight patients with essential hypertension (EH) before and after oral administration of captopril 25 mg. In RVH captopril reduced 51-Cr-EDTA clearance (67.3 (median) to 47.5 ml min-1, P less than 0.01), proximal absolute reabsorption of fluid (53.9 to 41.5 ml min-1, P less than 0.01) and distal absolute reabsorption of sodium (2195 to 1402 mumol min-1, P less than 0.01), whereas proximal fractional reabsorption increased slightly (77.5 to 80.2%, P less than 0.02). In EH, however, these parameters were practically unaffected by captopril. In both RVH and EH plasma concentrations of angiotensin II and aldosterone were reduced after captopril, but atrial natriuretic peptide in plasma and urinary excretion rate of prostaglandin E2 were unchanged. Blood pressure decreased after captopril in both groups, but the maximum fall in systolic BP was more pronounced in RVH (22%) than EH (13%). It is concluded that angiotensin converting enzyme inhibition markedly reduced absolute reabsorption in both the proximal and distal tubules in RVH, in contrast to EH, predominantly due...Continue Reading
References
Jul 1, 1978·Prostaglandins and Medicine·S Y TanP J Mulrow
Mar 15, 1976·Clinica Chimica Acta; International Journal of Clinical Chemistry·A M KappelgaardJ Giese
Feb 1, 1976·Prostaglandins·P Christensen, P P Leyssac
Apr 1, 1976·The American Journal of Physiology·C BaylisB M Brenner
Sep 16, 1985·Klinische Wochenschrift·H Sonnenberg
Apr 16, 1987·Nature·P J HarrisT O Morgan
Dec 1, 1987·International Journal of Cardiology·A R ThomassenE B Pedersen
May 1, 1986·Hypertension·I MiyamoriT Aburano
May 1, 1986·Circulation Research·B J Ballermann, B M Brenner
Apr 1, 1986·Clinical and Experimental Pharmacology & Physiology·J ZhuoS L Skinner
Aug 1, 1987·Hypertension·E FommeiL Donato
Aug 1, 1974·Kidney International·K Steven
Jan 1, 1981·Endocrinology·N R LevensR M Carey
Feb 1, 1981·Circulation Research·N R LevensR M Carey
Mar 1, 1984·Hypertension·W BenderW G Walker
May 31, 1984·The American Journal of Medicine·S C TextorF M Fouad
Feb 17, 1983·The New England Journal of Medicine·D E HricikV J Dzau
Feb 17, 1983·The New England Journal of Medicine·W B Blythe
May 1, 1984·Clinical Science·P J HarrisD W Ploth
Jan 1, 1984·Nephron·K Thomsen
Jan 1, 1984·Kidney International·J SchnermannP C Weber
Jan 1, 1980·Clinical Science·E S MarksJ D Swales
Dec 1, 1980·Clinical Science·K AbeK Yoshinaga
Jun 1, 1981·Kidney International·J P Kokko
Citations
May 1, 1991·Hypertension·M Martinez-Maldonado
Sep 22, 2005·Journal of Pharmacokinetics and Pharmacodynamics·Rune V OvergaardHenrik Madsen
Mar 1, 1997·Biological Trace Element Research·M R Naghii, S Samman