PMID: 8969930Nov 1, 1996Paper

Abnormal glucocorticoid activity in subjects with risk factors for cardiovascular disease

Endocrine Research
Brian R Walker

Abstract

There are striking similarities between Cushing's syndrome and the 'metabolic syndrome X' since both are characterised by hypertension, insulin resistance, glucose intolerance, hyperlipidaemia, and central obesity. The possibility that cortisol contributes to the associations between multiple risk factors for cardiovascular disease was rejected when it was demonstrated that there was no elevation in cortisol secretion or circulating concentration in patients with essential hypertension or type 2 diabetes mellitus. However, in recent years the enormous variability in tissue sensitivity to cortisol has become apparent. We have measured tissue sensitivity to glucocorticoids using an assay of skin vasoconstriction and have demonstrated its relationship with high blood pressure, insulin resistance, glucose intolerance, and hypertriglyceridaemia. Our data suggest that the increase in dermal glucocorticoid sensitivity is not a secondary phenomenon and may be explained by increased glucocorticoid receptor affinity together with impaired inactivation of cortisol by 11 beta-hydroxysteroid dehydrogenase. Importantly, we have not found that enhanced peripheral glucocorticoid sensitivity is associated with compensatory suppression of cortis...Continue Reading

References

Jun 1, 1992·Clinical Science·B R Walker, B C Williams
Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·A WajngotS Efendic
Aug 1, 1992·Metabolism: Clinical and Experimental·P MårinP Björntorp
May 1, 1982·The Journal of Clinical Endocrinology and Metabolism·R MarksJ W Funder
Nov 1, 1994·Molecular and Cellular Endocrinology·A L AlbistonZ S Krozowski
Jan 1, 1994·Acta Psychiatrica Scandinavica. Supplementum·A AromaaJ Maatela
Jun 1, 1963·The Journal of Clinical Endocrinology and Metabolism·A VERMEULEN, M VAN DER STRAETEN

❮ Previous
Next ❯

Citations

Oct 25, 2002·Journal of Women's Health & Gender-based Medicine·Enrique F SchistermanHoward Lewin
Aug 24, 2017·Psychosomatic Medicine·Mustafa alʼAbsi
Dec 13, 2003·The Journal of Clinical Endocrinology and Metabolism·C G PerryJ M C Connell
Nov 18, 2000·Hypertension·J A WhitworthJ J Kelly
Oct 16, 2008·Clinical and Experimental Hypertension : CHE·Apostolos HatzitoliosMaria Baltatzi
May 22, 2009·QJM : Monthly Journal of the Association of Physicians·R M ReynoldsB R Walker
Jul 6, 2005·British Journal of Pharmacology·Yakhin Shimoni
May 21, 2016·Inflammatory Bowel Diseases·Mathurin FumeryUNKNOWN EPIMAD group
Jun 6, 2007·Clinical Endocrinology·Giuseppe ReimondoMassimo Terzolo
Jun 5, 1999·The American Journal of Cardiology·S M Grundy
Jul 27, 1999·The Journal of Steroid Biochemistry and Molecular Biology·Z KrozowskiK E Sheppard
Jun 11, 2002·Biochemical and Biophysical Research Communications·Roland RosmondPer Björntorp
Jun 22, 2000·Medical Hypotheses·M F McCarty

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

© 2021 Meta ULC. All rights reserved