Abnormal glycemic homeostasis at the onset of serious mental illnesses: A common pathway

Psychoneuroendocrinology
Clemente Garcia-RizoMiquel Bernardo

Abstract

Patients with serious mental illnesses exhibit a reduced lifespan compared with the general population, a finding that can not solely rely on high suicide risk, low access to medical care and unhealthy lifestyle. The main causes of death are medical related pathologies such as type 2 diabetes mellitus and cardiovascular disease; however pharmacological treatment might play a role. We compared a two hour glucose load in naïve patients at the onset of a serious mental illness (N=102) (84 patients with a first episode of schizophrenia and related disorders, 6 with a first episode of bipolar I disorder and 12 with a first episode of major depression disorder) with another psychiatric diagnose, adjustment disorder (N=17) and matched controls (N=98). Young patients with serious mental illness showed an increased two hour glucose load compared with adjustment disorder and the control group. Mean two hour glucose values [±standard deviation] were: for schizophrenia and related disorders 106.51mg/dL [±32.0], for bipolar disorder 118.33mg/dL [±34.3], for major depressive disorder 107.42mg/dL [±34.5], for adjustment disorder 79.06mg/dL[±24.4] and for the control group 82.11mg/dL [±23.3] (p<0.001). Our results reflect an abnormal metabolic...Continue Reading

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Citations

Jan 4, 2017·European Psychiatry : the Journal of the Association of European Psychiatrists·C Garcia-RizoB Kirkpatrick
Apr 13, 2017·Early Intervention in Psychiatry·Shamima SaloojeeAyesha A Motala
Aug 9, 2017·Early Intervention in Psychiatry·Clemente Garcia-RizoMiquel Bernardo
May 30, 2019·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Megan GalballyMartien Snellen
Sep 11, 2019·European Psychiatry : the Journal of the Association of European Psychiatrists·Marina GarrigaMerete Osler
Dec 29, 2020·Frontiers in Neuroscience·Ruiqi FengFei Wang
Feb 1, 2020·Schizophrenia Research·Clemente García-RizoUNKNOWN PEPs GROUP
Apr 24, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Clemente García-RizoBenedicto Crespo-Facorro

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