Abnormal grooming activity in Dab1(scm) (scrambler) mutant mice

Behavioural Brain Research
C StrazielleR Lalonde

Abstract

Dab1(scm) mutant mice, characterized by cell ectopias and degeneration in cerebellum, hippocampus, and neocortex, were compared to non-ataxic controls for different facets of grooming caused by brief water immersions, as well as some non-grooming behaviors. Dab1(scm) mutants were strongly affected in their quantitative functional parameters, exhibiting higher starting latencies before grooming relative to non-ataxic littermates of the A/A strain, fewer grooming bouts, and grooming components of shorter duration, with an unequal regional distribution targeting almost totally the rostral part (head washing and forelimb licking) of the animal. Only bouts of a single grooming element were preserved. The cephalocaudal order of grooming elements appeared less disorganized, mutant and control mice initiating the grooming with head washing and forelimb licking prior to licking posterior parts. However, mutants differed from controls in that all their bouts were incomplete but uninterrupted, although intergroup difference for percentage of the incorrect transitions was not significant. In contrast to grooming, Dab1(scm) mice ambulated for a longer time. During walking episodes, they exhibited more body scratching than controls, possibly...Continue Reading

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Citations

May 28, 2013·Behavioural Brain Research·C JacquelinC Strazielle
Jan 22, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jun LiLifang Wang
Jul 24, 2020·International Journal of Nursing Practice·Manar Ali Bani-Hani, Ayman M Hamdan-Mansour
Aug 18, 2021·Neurobiology of Learning and Memory·L R SeemillerT J Gould

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