Abnormal heart rate and body temperature in mice lacking thyroid hormone receptor alpha 1

The EMBO Journal
L WikströmB Vennström

Abstract

Thyroid hormone, acting through several nuclear hormone receptors, plays important roles in thermogenesis, lipogenesis and maturation of the neonatal brain. The receptor specificity for mediating these effects is largely unknown, and to determine this we developed mice lacking the thyroid hormone receptor TR alpha 1. The mice have an average heart rate 20% lower than that of control animals, both under normal conditions and after thyroid hormone stimulation. Electrocardiograms show that the mice also have prolonged QRS- and QTend-durations. The mice have a body temperature 0.5 degrees C lower than normal and exhibit a mild hypothyroidism, whereas their overall behavior and reproduction are normal. The results identify specific and important roles for TR alpha 1 in regulation of tightly controlled physiological functions, such as cardiac pacemaking, ventricular repolarisation and control of body temperature.

References

Aug 11, 1991·Nucleic Acids Research·P W LairdA Berns
Jan 1, 1993·Annual Review of Physiology·D DiFrancesco
Jan 1, 1994·Thyroid : Official Journal of the American Thyroid Association·S Refetoff
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·J W Warmke, B Ganetzky
Jun 1, 1993·Endocrine Reviews·S RefetoffS J Usala
Jan 1, 1995·Annual Review of Nutrition·H C Freake, J H Oppenheimer
Dec 1, 1995·Thyroid : Official Journal of the American Thyroid Association·J E Silva

❮ Previous
Next ❯

Citations

Jul 25, 2009·Pflügers Archiv : European journal of physiology·Natig GassanovUta C Hoppe
Apr 28, 2005·Cell and Tissue Research·Denise R Holsberger, Paul S Cooke
Jan 9, 2009·The Cerebellum·Noriyuki Koibuchi
Jul 16, 2011·Hormones & Cancer·Maria AlexiadisPeter J Fuller
May 28, 2013·Trends in Molecular Medicine·Miguel LópezCarlos Diéguez
Sep 3, 2013·Seminars in Cell & Developmental Biology·Y M Vasquez, F J DeMayo
Sep 28, 2002·Trends in Genetics : TIG·Anna V Anagnostopoulos
Jun 5, 1998·Trends in Genetics : TIG·A V Anagnostopoulos
Jan 22, 2003·Peptides·J J G HillebrandR A H Adan
Sep 15, 2000·European Journal of Obstetrics, Gynecology, and Reproductive Biology·R KeijzerD Tibboel
Apr 18, 2001·Molecular and Cellular Endocrinology·N MessierM F Langlois
Jun 30, 2000·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·L M SachsA Ishizuya-Oka
Jun 1, 2001·The Journal of Steroid Biochemistry and Molecular Biology·J D BaxterT S Scanlan
Mar 26, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Paul WebbJohn D Baxter
Dec 29, 2000·Bioorganic & Medicinal Chemistry Letters·G ChielliniT S Scanlan
Jul 6, 2000·Trends in Endocrinology and Metabolism : TEM·Y Wu, R J Koenig
Feb 20, 2003·Trends in Endocrinology and Metabolism : TEM·Frédéric Flamant, Jacques Samarut
Oct 1, 2003·Trends in Endocrinology and Metabolism : TEM·J H Duncan Bassett, Graham R Williams
May 14, 1999·Trends in Endocrinology and Metabolism : TEM·Q LiA P Wolffe
Apr 20, 2002·Drug Discovery Today·Jan Törnell, Michael Snaith
Feb 13, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J M Fernández-RealR Estruch
Dec 16, 2011·The New England Journal of Medicine·Elena BochukovaKrishna Chatterjee
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·P E MacchiaS Refetoff
Aug 8, 2002·Thyroid : Official Journal of the American Thyroid Association·Clare B Harvey, Graham R Williams
Aug 8, 2002·Thyroid : Official Journal of the American Thyroid Association·W H Dillmann
May 12, 2000·Thyroid : Official Journal of the American Thyroid Association·E O AbuJ E Compston
Feb 26, 2000·Thyroid : Official Journal of the American Thyroid Association·D Forrest, B Vennström
Dec 29, 2000·Thyroid : Official Journal of the American Thyroid Association·C Wrutniak-CabelloG Cabello
Feb 3, 2005·Thyroid : Official Journal of the American Thyroid Association·Constantinos PantosDennis V Cokkinos
Feb 19, 2008·Thyroid : Official Journal of the American Thyroid Association·Maria-Jesus Obregon
Feb 19, 2008·Thyroid : Official Journal of the American Thyroid Association·Miriam O Ribeiro
Aug 7, 2013·Thyroid : Official Journal of the American Thyroid Association·Sunitha MeruvuPaul Webb
Oct 3, 2002·The EMBO Journal·Alexander TinnikovBjörn Vennström
Apr 29, 2005·Biology of Reproduction·Denise R HolsbergerPaul S Cooke

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.