Abnormal hemostatic function one year after orthotopic liver transplantation can be fully attributed to endothelial cell activation

Freeha ArshadTon Lisman


The long-term risk of thrombotic and vascular complications is elevated in liver transplant recipients compared to the general population. Patients with cirrhosis are in a hypercoagulable status during and directly after orthotopic liver transplantation, but it is unclear whether this hypercoagulability persists over time. We aimed to investigate the hemostatic status of liver transplant recipients one year after transplantation. We prospectively collected blood samples of 15 patients with a functioning graft one year after orthotopic liver transplantation and compared the hemostatic status of these patients with that of 30 healthy individuals. Patients one year after liver transplantation had significantly elevated plasma levels of von Willebrand factor (VWF). Thrombin generation, as assessed by the endogenous thrombin potential, was decreased in patients, which was associated with increased plasma levels of the natural anticoagulants antithrombin and tissue factor pathway inhibitor.  Plasma fibrinolytic potential was significantly decreased in patients and correlated inversely with levels of plasminogen activator inhibitor-1. One year after liver transplantation, liver graft recipients have a dysregulated hemostatic system ch...Continue Reading


Jan 1, 1997·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·A B Irish, F R Green
May 22, 1998·Transplantation Proceedings·M WeisW von Scheidt
Mar 18, 2000·Kidney International·S T MorrisA G Jardine
Mar 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ton LismanPhilip G De Groot
Sep 17, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Hugues JeanmartLouis P Perrault
Feb 24, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Armando TripodiPier Mannuccio Mannucci
Apr 2, 2005·British Journal of Haematology·Koichi KokameToshiyuki Miyata
Jul 26, 2006·The American Journal of Gastroenterology·Patrick G NorthupCarl L Berg
Apr 26, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Marco VivarelliAntonio D Pinna
Sep 18, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Maarten A J P BorgArie P van den Berg
Apr 30, 2008·Digestive Diseases and Sciences·David GulleySuthat Liangpunsakul
Dec 23, 2008·The American Journal of Gastroenterology·Kirstine Kobberøe SøgaardHenrik Toft Sørensen
May 9, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·I T A PereboomT Lisman
May 30, 2009·Journal of the American College of Surgeons·John P DuffyRonald W Busuttil
Oct 10, 2009·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Marco SenzoloTon Lisman
Mar 16, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Freeha ArshadRobert J Porte
Aug 3, 2013·Thrombosis Research·Marije C BaasFrederike J Bemelman

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Apr 11, 2017·Journal of Pediatric Gastroenterology and Nutrition·Carlos BilreiroÂngela Moreira

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