PMID: 9555793Apr 29, 1998Paper

Abnormal IgG cardiolipin antibody titers in patients with Raynaud's phenomenon and/or related disorders: prevalence and clinical significance

Journal of the American Academy of Dermatology
M VayssairatJ P Gaitz

Abstract

The prevalence of antibodies to cardiolipin (a-CL) in patients with Raynaud's phenomenon (RP) and/or related disorders (rD) is not known. The purpose of this study was to determine the prevalence of these antibodies. We assayed IgG a-CL in 230 consecutive patients with RP/rD and compared the results with those in a series of 230 control blood donors. Sixteen percent of patients were a-CL positive versus 7.8% of the control donors (p = 0.014). The prevalence of a-CL positivity was 8.7% for primary RP, 10.5% for secondary RP, 8% for chilblains, 25% for essential acrocyanosis, 20% for connective tissue diseases, and 17% for undifferentiated connective tissue diseases. Among patients with digital necrosis, 24% were a-CL positive. The prevalence of abnormal a-CL titers is higher in patients with RP/rD than in control donors, especially in patients with a connective tissue disease.

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Citations

Sep 21, 2000·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·M Knapik-Kordecka, W E Wysokinski
Dec 4, 2004·Current Opinion in Rheumatology·Eduardo J Cepeda, John D Reveille
Mar 4, 2000·Annals of the Rheumatic Diseases·P V VoulgariA A Drosos
Mar 24, 2011·Vascular Medicine·Andrew K KurklinskyThom W Rooke
Sep 22, 2016·Case Reports in Rheumatology·Mohammed ShabrawishiHani Almoallim
Jan 7, 2016·Anais Brasileiros De Dermatologia·Flavia Emilie HeimovskiThelma Larocca Skare
Apr 18, 2001·Journal of the European Academy of Dermatology and Venereology : JEADV·E VocksJ Ring
Apr 3, 2003·Pediatrics·Peter A NigrovicRobert P Sundel

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