Abnormal immunoexpression of cell adhesion molecules (CAMs) in cervical cancer

International Journal of Surgical Pathology
Morelva Toro de Méndez, Antonio Llombart Bosch

Abstract

The purpose of this study was to examine the immunoexpression of cell adhesion molecules (CAMs) E-cadherin, CD44s, and CD44v3 in cervical cancer and compare it with that in benign exo-endocervical tissue. In all, 81 cervical cancer biopsy specimens and 22 benign controls were included. Primary monoclonal antibodies NHC-38, F10-44-2, and 3G5 for E-cadherin, CD44s, and CD44v3 were used, respectively. Statistical significance was evaluated by the χ(2) test. Antigen expression was significantly different in cervical cancer specimens compared with controls, showing marked decrease in membrane expression: E-cadherin, 6.5% and 77.3% (P < .000); CD44s, 3.9% and 81.8% (P < .000); and CD44v3, 0% and 81.8% (P < .000), respectively. The immunoexpression was significantly heterogeneous in carcinomas (P < .034) and adenocarcinomas (P < .000) for E-cadherin and CD44s. For CD44v3, no case of cancer showed immunostaining in membranes. These findings reaffirm that cell adhesion is markedly altered in cervical cancer. The authors suggest that these proteins could serve as markers for invasive cervical neoplasia.

References

Mar 11, 1993·Nucleic Acids Research·C TölgH Ponta
Apr 15, 1996·Cancer·H ShiozakiM Monden
Aug 26, 1998·The American Journal of Pathology·S Hirohashi
Apr 15, 1999·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·E M IbrahimM Wells
May 7, 1999·Molecular Diagnosis : a Journal Devoted to the Understanding of Human Disease Through the Clinical Application of Molecular Biology·H GorhamD Tarin
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Nov 7, 2000·Cancer·A C HanH Salazar
May 20, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C L ChenH Y S Ngan
Aug 7, 2004·Gynecologic Oncology·Gregg Van de PutteRuth Holm
Jan 4, 2005·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·C Faleiro-Rodrigues, C Lopes
May 3, 2005·Gynecologic Oncology·María Alexandra Rodríguez-SastreAlejandro García-Carrancá
Aug 3, 2006·The Journal of Obstetrics and Gynaecology Research·Soon Cheol HongKyu Wan Lee
Sep 26, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kuan-Ting KuoMing-Chieh Lin
Oct 2, 2007·Apoptosis : an International Journal on Programmed Cell Death·Takeshi HagaJoel M Palefsky

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Citations

Oct 16, 2014·Acta Cirúrgica Brasileira·José Roosevelt CavalcantePaulo Roberto Carvalho Almeida
Nov 2, 2016·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Sandra LeeMáire A Duggan
Jun 6, 2017·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Sandra LeeMáire A Duggan

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Methods Mentioned

BETA
electrophoresis
PCR

Software Mentioned

SPSS

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