Abnormal inhibition-excitation imbalance in migraine

Cephalalgia : an International Journal of Headache
Bao N NguyenAlgis J Vingrys

Abstract

People with migraine show increased surround suppression of perceived contrast, a perceptual analogue of centre-surround antagonistic interactions in visual cortex. A proposed mechanism is that cortical 'hyperexcitability' or 'hyperresponsivity', a prominent theory in the migraine literature, drives abnormal excitatory-inhibitory balance to give increased local inhibition. The purpose of this cross-sectional study was to determine whether cortical hyperresponsivity and excitatory-inhibitory imbalance manifests in the visual cortical response of migraine sufferers. Interictal steady-state visual evoked potentials (VEPs) in response to 0 to 97% contrast were recorded in 30 migraine participants (15 without aura, 15 with aura) and 21 non-headache controls. Monotonicity indices were calculated to determine response saturation or supersaturation. Contrast gain was modelled with a modified saturating hyperbolic function to allow for variation in excitation and inhibition. A greater proportion of migraine participants (43%) than controls (14%) exhibited significant VEP supersaturation at high contrast, based on monotonicity index (chi-square, p = 0.028). Supersaturation was also evident by the trend for greater suppressive exponent va...Continue Reading

References

Aug 1, 1992·Visual Neuroscience·D J Heeger
Oct 22, 1991·Proceedings. Biological Sciences·J Ross, H D Speed
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C ChubbJ A Solomon
Oct 1, 1989·Archives of Neurology·D A Marcus, M J Soso
Aug 1, 1973·Vision Research·H SpekreijseT Zuidema
Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·V Zemon, F Ratliff
Jul 1, 1982·Journal of Neurophysiology·D G Albrecht, D B Hamilton
May 27, 1994·Science·M Carandini, D J Heeger
Mar 4, 2000·Nature Neuroscience·V PorciattiR Guerrini
Aug 17, 2000·Documenta Ophthalmologica. Advances in Ophthalmology·T Meigen, M Bach
Jan 6, 2001·Documenta Ophthalmologica. Advances in Ophthalmology·D C Hood, X Zhang
Apr 17, 2001·Cephalalgia : an International Journal of Headache·A J Shepherd
Apr 10, 2002·Neurology·Lorella BattelliShirley H Wray
Apr 18, 2003·Cephalalgia : an International Journal of Headache·A AmbrosiniJ Schoenen
Apr 21, 2004·Cephalalgia : an International Journal of Headache·A M McKendrick, D R Badcock
Oct 26, 2005·Current Biology : CB·Steven DakinDavid Hemsley
Jun 17, 2006·Human Brain Mapping·Francesco Di RussoSteven A Hillyard
Aug 22, 2006·Cephalalgia : an International Journal of Headache·A M McKendrickM Gurgone
Oct 20, 2006·PLoS Medicine·Cristina GranzieraNouchine Hadjikhani
Aug 19, 2007·CNS & Neurological Disorders Drug Targets·Anja Puppe, Volker Limmroth
Aug 19, 2007·CNS & Neurological Disorders Drug Targets·Michail Vikelis, Dimos D Mitsikostas
Nov 24, 2007·Cephalalgia : an International Journal of Headache·G CoppolaJ Schoenen
Nov 24, 2007·Cephalalgia : an International Journal of Headache·S K Aurora, F Wilkinson
Mar 1, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Trond SandLars Jacob Stovner
Aug 1, 2008·The Journal of Headache and Pain·Alessandro Panconesi
Aug 5, 2008·Neurobiology of Learning and Memory·Gianluca CoppolaJean Schoenen
Jul 17, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Julie D GolombZubin Bhagwagar
Sep 18, 2009·Journal of Vision·Renee Karas, Allison M McKendrick
Oct 15, 2009·Documenta Ophthalmologica. Advances in Ophthalmology·J Vernon Odom Vaegan
Dec 8, 2009·Progress in Neurobiology·François-Benoît VialatteAndrzej Cichocki
May 28, 2010·Investigative Ophthalmology & Visual Science·Josephine BattistaAllison M McKendrick
Aug 10, 2010·Cephalalgia : an International Journal of Headache·Andrea AntalPeter Dechent
Nov 19, 2010·Documenta Ophthalmologica. Advances in Ophthalmology·Kumiko IshikawaMakoto Nakamura
Apr 16, 2011·Cephalalgia : an International Journal of Headache·Olivera KaranovicFrances Wilkinson
Apr 16, 2011·PloS One·Josephine BattistaAllison M McKendrick
Jun 29, 2011·Annals of Neurology·Jeffrey J TsaiAlex R Wade
May 29, 2012·Trends in Neurosciences·Dania Vecchia, Daniela Pietrobon

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Citations

Aug 23, 2016·Expert Review of Neurotherapeutics·Carlo LovatiClaudio Mariani
Feb 1, 2019·Investigative Ophthalmology & Visual Science·Jia Jia LekAlgis J Vingrys
Apr 28, 2016·Current Opinion in Neurology·Delphine MagisGianluca Coppola
Dec 5, 2019·The Journal of Headache and Pain·Tobias G StærmoseJakob U Blicher
Aug 11, 2018·The Journal of Headache and Pain·Giuseppe CosentinoFilippo Brighina
Aug 28, 2021·Vision·Xim Cerda-CompanyXavier Otazu

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