Abnormal inhibition of return in mild cognitive impairment: is it specific to the presence of prodromal dementia?

Journal of Alzheimer's Disease : JAD
Antony BayerAndrea Tales

Abstract

Although there is some evidence that amnestic mild cognitive impairment (aMCI) can be characterized by significant deficits in visuospatial function, the cross-sectional design of the majority of these studies renders it impossible to determine whether such deficits occur in aMCI as a result of, or accompany, amnestic dysfunction per se or whether they are the result of disproportionately poorer performance in a sub-group of patients for whom aMCI represents prodromal dementia. Similarly, whether the absence of aMCI-related functional deficit stems from the masking of dementia-specific abnormality by the preserved performance of those with a different cause of aMCI cannot be ascertained. Here we report the outcome of a cross-sectional and 2.5-year longitudinal evaluation follow-up, computer-based study of visuospatial attention, specifically attentional disengagement and inhibition of return and the mean (RTSPEED) and intra-individual variability (IIVRT) of their component reaction times, in 45 patients with aMCI and 31 cognitively healthy older adults. Reduced inhibition of return (p = 0.01 and p = 0.037 in response to 400 and 800 ms cue to target interval conditions), slowed RTSPEED (p = 0.038 and p = 0.03 in response to 400 ...Continue Reading

Citations

Dec 22, 2020·Frontiers in Aging Neuroscience·Ibrahim AlmubarkXiong Jiang
Oct 17, 2020·Frontiers in Psychiatry·Andrew P OwensDag Aarsland
Jan 5, 2021·Alzheimer's & Dementia : Translational Research & Clinical Interventions·David BissigDeniz Erten-Lyons
Aug 31, 2021·Applied Neuropsychology. Adult·Karl S GrewalDebra Morgan
Aug 14, 2019·Dementia and Geriatric Cognitive Disorders·Daniela AndriutaOlivier Godefroy

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