Abnormal Injury Response in Spontaneous Mild Ventriculomegaly Wistar Rat Brains: A Pathological Correlation Study of Diffusion Tensor and Magnetization Transfer Imaging in Mild Traumatic Brain Injury

Journal of Neurotrauma
Tsang-Wei TuJoseph A Frank

Abstract

Spontaneous mild ventriculomegaly (MVM) was previously reported in ∼43% of Wistar rats in association with vascular anomalies without phenotypic manifestation. This mild traumatic brain injury (TBI) weight drop model study investigates whether MVM rats (n = 15) have different injury responses that could inadvertently complicate the interpretation of imaging studies compared with normal rats (n = 15). Quantitative MRI, including diffusion tensor imaging (DTI) and magnetization transfer imaging (MTI), and immunohistochemistry (IHC) analysis were used to examine the injury pattern up to 8 days post-injury in MVM and normal rats. Prior to injury, the MVM brain showed significant higher mean diffusivity, axial diffusivity, and radial diffusivity, and lower fractional anisotropy (FA) and magnetization transfer ratio (MTR) in the corpus callosum than normal brain (p < 0.05). Following TBI, normal brains exhibited significant decreases of FA in the corpus callosum, whereas MVM brains demonstrated insignificant changes in FA, suggesting less axonal injury. At day 8 after mild TBI, MTR of the normal brains significantly decreased whereas the MTR of the MVM brains significantly increased. IHC staining substantiated the MRI findings, demon...Continue Reading

References

Feb 1, 1994·Journal of Neurosurgery·A MarmarouK Demetriadou
Aug 23, 2001·Medical Image Analysis·M Jenkinson, S Smith
Mar 22, 2002·NeuroImage·Christopher R GenoveseThomas Nichols
Jun 23, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marios C PapadopoulosA S Verkman
Nov 24, 2005·Journal of Cell Science·Samira SaadounA S Verkman
Apr 21, 2006·Experimental Neurology·Osaama H KhanMarc R Del Bigio
May 5, 2006·Acta Neurochirurgica. Supplement·T KuroiwaK Ohno
Jun 9, 2007·Cerebrospinal Fluid Research·Janet M Miller, James P McAllister
Nov 28, 2007·AJNR. American Journal of Neuroradiology·D R RutgersD Ducreux
Sep 17, 2008·American Journal of Medical Genetics. Part a·Chayim Can Schell-ApacikHubertus von Voss
Aug 18, 2010·Experimental Neurology·Kelley E DerenJames P McAllister
Nov 23, 2010·Nature Reviews. Immunology·Grace Y Chen, Gabriel Nuñez
May 13, 2011·Journal of Magnetic Resonance Imaging : JMRI·Irene M VavasourAlex L MacKay
Aug 19, 2011·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Ramin EskandariJames P McAllister
Oct 21, 2011·Journal of Neuroinflammation·Thomas TourdiasVincent Dousset
Dec 16, 2011·Brain : a Journal of Neurology·Yong WangSheng-Kwei Song
Jul 18, 2012·Seminars in Fetal & Neonatal Medicine·James P McAllister
Oct 24, 2012·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Karen Y OhRoya Sohaey
Dec 12, 2012·NMR in Biomedicine·L Christine TurtzoJoseph A Frank
Nov 23, 2013·Science·Jennifer Couzin-Frankel
Mar 14, 2014·Archives of Gynecology and Obstetrics·Rie NoguchiHiroyuki Yoshikawa
Mar 26, 2014·Pediatrics·Shailly Jain-GhaiSaadet Mercimek-Mahmutoglu
Nov 11, 2014·Journal of Neuropathology and Experimental Neurology·Tsang-Wei TuJoseph A Frank
Jul 4, 2015·Neuron·Sachin P GadaniJonathan Kipnis

❮ Previous
Next ❯

Citations

Jan 22, 2019·Journal of Neurotrauma·Colleen N BodnarAdam D Bachstetter
Nov 9, 2019·Journal of Neurotrauma·Zhou ZhouSvein Kleiven
Jun 26, 2020·Brain and Behavior·Hiram Luna-MunguiaLuis Concha
May 29, 2020·Brain : a Journal of Neurology·Ronel VekslerAlon Friedman
Jan 8, 2021·Acta Neuropathologica Communications·Xuan Vinh To, Fatima A Nasrallah

❮ Previous
Next ❯

Software Mentioned

Matlab
Tortoise
CellC
TBSS
FLIRT
GraphPad
Prism
ImageJ

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.