Abnormal intracellular distribution of NFAT1 in T lymphocytes from patients with systemic lupus erythematosus and characteristic clinical features

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Yuko FujiiYoshiya Tanaka

Abstract

Systemic lupus erythematosus (SLE) presents various clinical features; however, underlying mechanisms remain unclear. In the immunity of SLE, impaired T cell receptor (TCR) signaling and altered cytokine production are in the center of pathogenesis, although, little is known about NFAT (nuclear factor of activated T cells) in lupus T lymphocytes. TCR stimulation activates NFAT1 through Ca2+/calcineurin (Cn) pathway, facilitating nuclear translocation of NFAT1 from cytosol. Therefore, we investigated relationship of disease activity/features and intracellular NFAT1 localization in T lymphocytes from active lupus patients by fractionation. Results showed no significant relationship between disease activity and NFAT1 distribution. However, interestingly, we observed skewed NFAT1 distribution in pellet in patients with active lupus nephritis or pleuritis. In vitro cyclosporin A treatment suggested autonomously activated Ca2+/Cn pathway in lupus T lymphocytes. Considering these results, NFAT1 might be presenting the clinical heterogeneity in SLE.

References

Aug 1, 1991·Clinical Immunology and Immunopathology·Y TadaY Niho
Nov 2, 1984·Science·R E HandschumacherD W Speicher
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Nov 21, 1995·Proceedings of the National Academy of Sciences of the United States of America·K T ShawP G Hogan
Mar 1, 1995·Clinical and Experimental Immunology·H BeckerK Federlin
Jul 1, 1994·The Journal of Clinical Investigation·G M KammerC J Malemud
Jul 1, 1996·The Journal of Experimental Medicine·C LuoA Rao
Mar 28, 1997·Science·C R BealsG R Crabtree
May 1, 1997·Molecular and Cellular Biology·L LyakhN R Rice
Jan 1, 1997·Annual Review of Immunology·A RaoP G Hogan
Jun 2, 1998·Lupus·R Herrera-EsparzaE Avalos-Díaz
Aug 14, 1999·Arthritis and Rheumatism·M AkahoshiY Niho
Jun 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S FeskeA Rao
Aug 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·N MishraG M Kammer
Nov 30, 2000·The Journal of Biological Chemistry·E E Corcoran, A R Means
Mar 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·E E SolomouG C Tsokos
Jul 13, 2002·Arthritis and Rheumatism·Gary M KammerGeorge C Tsokos
Oct 2, 2002·European Journal of Immunology·Silvia Monticelli, Anjana Rao
Jul 2, 2003·Journal of Clinical Pathology·C C Mok, C S Lau
Sep 17, 2003·Genes & Development·Patrick G HoganAnjana Rao
May 4, 2004·Molecular and Cellular Biology·Heidi OkamuraAnjana Rao
Aug 18, 2004·Current Opinion in Rheumatology·Vasileios C Kyttaris, George C Tsokos
Mar 1, 2005·Lupus·M Aringer, J S Smolen
Mar 1, 2005·Lupus·M Waldman, M P Madaio
Apr 21, 2005·The Journal of Clinical Investigation·Gary M Kammer
Jun 2, 2005·Nature Reviews. Immunology·Fernando Macian

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.