Abnormal laboratory findings and plasma concentration monitoring of lopinavir and ritonavir in COVID-19.

British Journal of Clinical Pharmacology
Benjamin BatteuxYoussef Bennis

Abstract

It is not known whether the adverse events (AEs) associated with the administration of lopinavir and ritonavir (LPV/r) in the treatment of COVID-19 are concentration-dependent. In a retrospective study of 65 patients treated with LPV/r and therapeutic drug monitoring (TDM) for severe forms of COVID-19 (median age: 67; males: 41 [63.1%]), 33 (50.8%) displayed a grade ≥2 increase in plasma levels of hepatobiliary markers, lipase and/or triglycerides. A causal relationship between LPV/r and the AE was suspected in 9 of the 65 patients (13.8%). At 400 mg b.i.d., the plasma trough concentrations of LPV/r were high and showed marked interindividual variability (median [interquartile range]: 16,600 [11,430-20,842] ng/ml for lopinavir and 501 [247-891] ng/ml for ritonavir). The trough lopinavir concentration was negatively correlated with body mass index, while the trough ritonavir concentration was positively correlated with age and negatively correlated with prothrombin activity. However, the occurrence of abnormal laboratory values was not associated with higher trough plasma concentrations of LPV/r. Further studies will be needed to determine the value of TDM in LPV/r-treated patients with COVID-19.

References

Nov 4, 2000·Biochimica Et Biophysica Acta·T FournierD Porquet
Aug 7, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Félix GutiérrezAlberto Martin-Hidalgo
Sep 18, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David C RhewMatthew Bidwell Goetz
Nov 1, 2003·AIDS Patient Care and STDs·Daniel González de RequenaVincent Soriano
Mar 18, 2004·British Journal of Clinical Pharmacology·Caroline SolasBruno Lacarelle
Jan 4, 2005·Journal of Immunological Methods·Stéphane AzoulayDanièle Duval
Jun 7, 2005·Expert Opinion on Drug Safety·Martin Vogel, Jürgen K Rockstroh
Sep 7, 2005·The Journal of Antimicrobial Chemotherapy·Elena SeminariAntonella Castagna
Nov 10, 2009·The Journal of Antimicrobial Chemotherapy·Wolfgang StöhrUNKNOWN UK CHIC Steering Committee
Sep 14, 2011·Therapeutic Drug Monitoring·Elena López AspirozMaría José García Sánchez
Oct 22, 2017·British Journal of Pharmacology·Stephen Ph AlexanderUNKNOWN CGTP Collaborators
Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19
Mar 19, 2020·The New England Journal of Medicine·Bin CaoChen Wang
May 4, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Dwight L McKeeCord Naujokat

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

HIV/AIDS : Research and Palliative Care
Beatriz Larru Martinez, F Andrew I Riordan
Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Khanita DuangchaemkarnManupat Lohitnavy
© 2021 Meta ULC. All rights reserved