Abnormal labyrinthine zone in the Hectd1-null placenta

Placenta
Anjali A SarkarIrene E Zohn

Abstract

The labyrinthine zone of the placenta is where exchange of nutrients and waste occurs between maternal and fetal circulations. Proper development of the placental labyrinth is essential for successful growth of the developing fetus and abnormalities in placental development are associated with intrauterine growth restriction (IUGR), preeclampsia and fetal demise. Our previous studies demonstrate that Hectd1 is essential for development of the junctional and labyrinthine zones of the placenta. Here we further characterize labyrinthine zone defects in the Hectd1 mutant placenta. The structure of the mutant placenta was compared to wildtype littermates using histological methods. The expression of cell type specific markers was examined by immunohistochemistry and in situ hybridization. Hectd1 is expressed in the labyrinthine zone throughout development and the protein is enriched in syncytiotrophoblast layer type I cells (SynT-I) and Sinusoidal Trophoblast Giant cells (S-TGCs) in the mature placenta. Mutation of Hectd1 results in pale placentas with frequent hemorrhages along with gross abnormalities in the structure of the labyrinthine zone including a smaller overall volume and a poorly elaborated fetal vasculature that contain...Continue Reading

References

Oct 1, 1994·Molecular Endocrinology·F ChenB W O'Malley
Jan 6, 1999·Proceedings of the National Academy of Sciences of the United States of America·M I MorassoK A Mahon
Mar 25, 1999·Genes & Development·J GalceranR Grosschedl
Sep 7, 2001·Developmental Biology·B A ParrA P McMahon
Feb 20, 2004·Biology of Reproduction·Philip M CoanGraham J Burton
Aug 19, 2006·Differentiation; Research in Biological Diversity·James C CrossErica D Watson
Sep 12, 2006·Developmental Biology·Motoko AokiHitoshi Okamoto
Feb 10, 2007·Developmental Biology·David G SimmonsJames C Cross
May 24, 2014·Developmental Biology·Anjali A SarkarIrene E Zohn

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Citations

Jun 28, 2017·International Journal of Molecular Sciences·Dale McAninchTina Bianco-Miotto
Dec 24, 2018·Disease Models & Mechanisms·Kelsey F SugrueIrene E Zohn

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