Abnormal language-related oscillatory responses in primary progressive aphasia

NeuroImage. Clinical
Aneta KielarJed A Meltzer

Abstract

Patients with Primary Progressive Aphasia (PPA) may react to linguistic stimuli differently than healthy controls, reflecting degeneration of language networks and engagement of compensatory mechanisms. We used magnetoencephalography (MEG) to evaluate oscillatory neural responses in sentence comprehension, in patients with PPA and age-matched controls. Participants viewed sentences containing semantically and syntactically anomalous words that evoke distinct oscillatory responses. For age-matched controls, semantic anomalies elicited left-lateralized 8-30 Hz power decreases distributed along ventral brain regions, whereas syntactic anomalies elicited bilateral power decreases in both ventral and dorsal regions. In comparison to controls, patients with PPA showed altered patterns of induced oscillations, characterized by delayed latencies and attenuated amplitude, which were correlated with linguistic impairment measured offline. The recruitment of right hemisphere temporo-parietal areas (also found in controls) was correlated with preserved semantic processing abilities, indicating that preserved neural activity in these regions was able to support successful semantic processing. In contrast, syntactic processing was more consi...Continue Reading

Citations

Aug 14, 2020·Brain : a Journal of Neurology·Valentina BorghesaniSrikantan S Nagarajan
Sep 13, 2019·Journal of the International Neuropsychological Society : JINS·Jet M J VonkLoraine K Obler
Oct 13, 2020·Language and Linguistics Compass·Yanina Prystauka, Ashley Glen Lewis
Nov 16, 2021·The European Journal of Neuroscience·Roksana MarkiewiczAli Mazaheri

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Methods Mentioned

BETA
PCA
Extraction

Software Mentioned

EEGLAB
3dClustSim
SAM
SPM8
Synthetic Aperture Magnetometry ( SAM )
DARTEL ( Diffeomorphic Anatomical Registration through Exponen...
SPSS
ANTS
Matlab
Brain Extraction Tool

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Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.