PMID: 8606883Nov 1, 1995Paper

Abnormal levels of maternal serum human chorionic gonadotropin and alpha-fetoprotein in the second trimester: relation to fetal weight and preterm delivery

Prenatal Diagnosis
L P MorssinkA Mantingh

Abstract

The aim of this prospective descriptive cross-sectional study was to examine the clinical significance of abnormal maternal serum human chorionic gonadotropin (MShCG) and alpha-fetoprotein (MSAFP) in the second trimester of pregnancy. The study group comprised 8892 women with a singleton pregnancy, who were screened for a neural tube defect and Down's syndrome. Exclusion criteria were unknown pregnancy outcome, a congenital anomaly, delivery before 25 weeks of amenorrhoea, or known insulin-dependent diabetes. MSAFP and MShCG were determined between 15 and 20 weeks' amenorrhoea. An abnormal result was defined as (a) MSAFP or MShCG > or = 2.5 MOM, (b) MSAFP or MShCG < or = 0.5 MOM, and (c) MSAFP and MShCG > or = 2.5 MOM. Birth weight percentiles and the duration of amenorrhoea at the time of delivery were employed as outcome parameters. Of the women with an abnormally elevated MSAFP, 9.4 per cent had an extremely small-for-gestational age (SGA) infant (< 2.3rd percentile; P < 0.01, relative risk 4.5), 27.1 per cent had an SGA infant (< tenth percentile; P < 0.01, relative risk 2.7), and 14.3 per cent had an appropriate-for-gestational age (AGA) infant that was delivered preterm (< 259 days; P < 0.01, relative risk 2.4). In the ca...Continue Reading

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Citations

Mar 1, 1997·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·L S Onderoğlu, A Kabukçu
Jun 1, 2002·Obstetrics and Gynecology·Ahmet A BaschatJane A Evans
Dec 30, 1999·The New England Journal of Medicine·D L WaltonC J Colby
Jul 21, 1999·European Journal of Obstetrics, Gynecology, and Reproductive Biology·L P Morssink
Oct 6, 2005·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Reli HershkovitzMoshe Mazor
Mar 1, 1997·Obstetrics and Gynecology Clinics of North America·H L Ross, S Elias
Jul 10, 2003·Clinics in Laboratory Medicine·Charles J Lockwood
Apr 29, 2006·American Journal of Obstetrics and Gynecology·Dena TownerDina El Kady
Jun 30, 2000·Human Reproduction·R Al-MuftiK H Nicolaides
Aug 1, 1996·Prenatal Diagnosis·U TantravahiP Benn
Mar 18, 2011·Fetal Diagnosis and Therapy·Jarek BetaKypros H Nicolaides
Jul 13, 2019·Prenatal Diagnosis·Stephen TongTeresa Mary MacDonald
Feb 13, 2003·Acta Obstetricia Et Gynecologica Scandinavica·Reli HershkovitzMoshe Mazor
Dec 28, 1999·Human Reproduction·R Al-MuftiK H Nicolaides
Jul 17, 2021·Prenatal Diagnosis·Monique PerisDavid J Amor

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