Sep 1, 1977

Abnormal lipid accumulation within the small intestinal mucosa of children with juvenile-onset diabetes mellitus

American Journal of Diseases of Children
R C BoboK Saalfeld

Abstract

The lipid content of the proximal jejunum, as studied by light microscopy with lipid histochemical staining methods, is determined in 14 fasting children with juvenile-onset diabetes mellitus. The results show that four children had greatly increased amounts of lipid, while six others had a mildly to moderately increased amounts of lipid present. The amount of lipid present appears to correlate most closely with the quality of control of the diabetes. These results indicate either that the clearance of exogenous lipid is impaired or that there is an increased endogenous synthesis of lipid within the intestine of the diabetic child, especially in those under poor control.

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Mentioned in this Paper

Epicholesterol
Malignant Neoplasm of Jejunum
Small Intestine Mucous Membrane
Structure of Intestinal Gland
Intestinal Wall Tissue
Entire Jejunum
Diabetes Mellitus, Insulin-Dependent
Diabetes, Autoimmune
Lipids
Intestines

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