Abnormal lipid metabolism and renal disorders

The Tohoku Journal of Experimental Medicine
T Saito

Abstract

Abnormal renal diseases including nephrotic syndrome and chronic renal failure are associated with hyperlipidemia, significance of abnormal lipid metabolism has been thought to be limited in some inherited renal diseases. However, recent studies have postulated that glomerulosclerosis is induced by hyperlipidemia and is in common with atherosclerosis. This involvement is found in the progressive renal disorders, e.g., focal glomerular sclerosis, diabetic nephropathy and glycogen storage disease. Interaction between macrophages and mesangial cells may play an important role in such conditions. This evidence is supported by experimental models with hyperlipidemia. On the other hand, discovery and new hereditary metabolic disorders, such as type III hyperlipoproteinemia and lipoprotein glomerulopathy, shows that apolipoprotein (apo) E abnormalities are responsible for the glomerular lesions. Especially, lipoprotein glomerulopathy has specific features different from those of lipid-induced renal diseases. In this disease, apo E Sendai which results from new substitution (Arginine 145-->Proline) may induce intraglomerular lipoprotein thrombi characteristic of lipoprotein glomerulopathy.

References

Feb 1, 1975·Annals of Internal Medicine·D S FredricksonR I Levy
Nov 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S OikawaT Toyota
Jan 1, 1990·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·K P HarrisS Klahr
Mar 1, 1990·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Y KoitabashiH Sakaguchi
Feb 1, 1989·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·T SaitoH Sakaguchi
Jun 1, 1989·Kidney International·L BakerS Heyman
Jan 1, 1988·American Journal of Nephrology·W F KeaneM P O'Donnell
Jul 1, 1987·Human Pathology·T Faraggiana, J Churg
Jan 7, 1988·The New England Journal of Medicine·Y T ChenJ B Sidbury
Nov 1, 1987·Kidney International·J R Diamond, M J Karnovsky
Feb 1, 1987·Metabolism: Clinical and Experimental·G M Reaven
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·N A ElshourbagyJ M Taylor
Dec 1, 1973·Kidney International·R Habib
Sep 15, 1981·The Biochemical Journal·F Assimacopoulos-JeannetB Jeanrenaud
Jan 1, 1983·Annual Review of Biochemistry·M S Brown, J L Goldstein
Jan 1, 1995·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·A MeyrierB Mougenot
Dec 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·P ZhangG Gallo
Feb 1, 1993·Comparative Biochemistry and Physiology. Comparative Physiology·R Rossi, E Scharrer
Jul 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D Schlondorff
Jan 1, 1993·American Journal of Nephrology·T SaitoH Sakaguchi
May 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·T FurutaK Yoshinaga
Oct 1, 1995·Journal of the American Society of Nephrology : JASN·D EllisJ R Diamond
May 1, 1997·Journal of the American Society of Nephrology : JASN·S OikawaJ Sasaki
Jan 1, 1997·Contributions to Nephrology·T SaitoJ Chiba

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Citations

Mar 29, 2002·Lancet·B D Fox
Oct 9, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Zhang XinLi Leishi
Sep 24, 2005·Nephron. Experimental Nephrology·Yixiang ZhangHirohito Tsubouchi
Jun 1, 2000·Kidney International. Supplement·W F Keane
Feb 19, 2002·Kidney International·Thorsten P DegenhardtJohn W Baynes
Mar 6, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Mikito HayakawaAkira Yamada
Jan 25, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Takao SaitoShinichi Oikawa
Jan 11, 2014·Critical Reviews in Clinical Laboratory Sciences·A D MaraisD J Blom
May 22, 2009·Clinical and Experimental Nephrology·Atsunori IshimuraTakao Saito
Jul 30, 2002·Neonatal Network : NN·C W Jones
Feb 22, 2001·Journal of the American Society of Nephrology : JASN·Michael M HoffmannWinfried März

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