Abnormal lipid metabolism in a rat model of arthritis: one possible pathway

Molecular and Cellular Biochemistry
Niraj Kumar SrivastavaDeepak Sharma

Abstract

Collagen-induced arthritis (CIA) animal model is associated with systemic manifestations, including alteration of lipid metabolism. In the present study, one possible pathway of altered lipid metabolism is proposed. Specimens of joint tissue and plasma were collected from the CIA and control rats, and quantitative analysis of lipid components was performed by nuclear magnetic resonance (NMR) spectroscopy technique. Correlation analysis was performed between the level of lipid components and antioxidant enzymes, lactate dehydrogenase (LDH), lipid peroxidation (LP), and cytokines in joint tissue and plasma. Differentiation between the CIA and control rats was established on the basis of the quantity of lipid components in the joint tissue and plasma. Positive correlation was observed for all the enzymes vs. lipid components as well as LP vs. lipid components in plasma and joint tissue. Positive correlation was observed for enzymes in plasma and joint tissue. A negative correlation was observed in between the plasma and joint tissue with the level of lipid components. Cytokine levels were also correlated with the level of lipid components and ratios of saturated fatty acids/unsaturated fatty acids in plasma and joint tissue. Infla...Continue Reading

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Citations

Jan 18, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Huan ChenShijun Xu

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Methods Mentioned

BETA
NMR
X-ray
light microscopy
ELISA

Software Mentioned

SPSS
SoftMax Pro

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