Abnormal lipoprotein phospholipid composition in patients with essential hypertension

Atherosclerosis
J D BagdadeH Lithell

Abstract

Vascular cell membranes from patients with essential hypertension (EH) and animals with genetic forms of hypertension have been found to have alterations in the content of free cholesterol and negatively charged phospholipids that may modify their function. Since membrane and lipoprotein lipids exchange freely, the lipid composition of lipoproteins may be an indirect measure of the content of vascular and other cells. To determine whether abnormalities are present in the lipid and phospholipid composition of lipoproteins from patients with EH, 30 EH (11 women; 19 men) and 20 normotensive control subjects were studied. Since significant gender differences were present in a number of parameters of lipoprotein composition, male and female data were examined separately. The EH group of both sexes tended to have higher plasma TG and VLDL + LDL and HDL2 lipid levels than their respective controls. Not only were the calcium-binding phospholipids phosphatidylinositol (PI) + phosphatidylserine (PS), and the membrane fluidizer phosphatidylethanolamine (PE) were significantly reduced in their VLDL + LDL, but all phospholipids (L, sphingomyelin (SPH), PI + PS, and PE) were significantly reduced in their neutral lipid content in both the HD...Continue Reading

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Citations

Sep 17, 1999·Atherosclerosis·K A RyeP J Barter
Mar 25, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity·Hong Feng, Xiang-An Li
Feb 23, 2012·Scientific Reports·Monireh DashtiFarhad Rezaee
May 27, 2004·Journal of the American Geriatrics Society·Rachel P WildmanLewis H Kuller
Apr 7, 1998·JPEN. Journal of Parenteral and Enteral Nutrition·R L MossR H Glew
Aug 7, 1999·The Journal of Biological Chemistry·P Y Wang, R S Munford
Feb 1, 2020·Journal of Hypertension·William J HeTanika N Kelly
Jul 11, 2018·International Journal of Molecular Sciences·Sarina KajaniFiona C McGillicuddy

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