Abstract
Acute lymphoblastic leukemia (ALL) is the most common malignancy in childhood. While hepatitis is a well-known complication during the treatment phase of ALL, the association of abnormal liver biochemistries at initial presentation of leukemia is poorly described. The aim of this study is to examine the prevalence and assess the clinical impact of hepatitis at diagnosis in children with ALL. All children diagnosed with ALL at BC Children's Hospital between 2001 and 2006 were included. Charts were reviewed and data recorded to a computerized spreadsheet. Descriptive statistical analyses were performed. One hundred forty-seven ALL patients were identified. Over one third of patients had abnormal liver transaminase values (AST and/or ALT). Of the patients with abnormal transaminases, (52%) had ALT elevations twice the upper limit of normal. Risk factors for elevated transaminases included a high WBC count at diagnosis, older age, bulky disease, and T-cell leukemia. Conjugated hyperbilirubinemia was observed in 3.4% of subjects. Of these cases, 60% received steroids prior to induction chemotherapy and all had rapid resolution of their hyperbilirubinemia to normal levels. Elevated transaminases are common at initial presentation of ...Continue Reading
References
Aug 11, 1992·Journal of Pediatric Gastroenterology and Nutrition·E E ConwayS Mitsudo
Feb 1, 1992·Gastroenterology·M B CohenJ E Heubi
Jun 1, 1987·Clinical Pharmacology and Therapeutics·M V RellingW E Evans
Dec 1, 1973·Clinical Pediatrics·R G McCordP J Joo
Jan 1, 1983·The American Journal of Pediatric Hematology/oncology·J M HarbE L Blank
Apr 1, 1995·Histopathology·I B ScheimbergJ D van der Walt
Nov 1, 1993·Journal of Pediatric Gastroenterology and Nutrition·R Gonzalez-VallinaP F Whitington
Jan 20, 1996·BMJ : British Medical Journal·A GoughE Elias
Jan 1, 1996·Journal of Pediatric Gastroenterology and Nutrition·D DevictorE Dussaix
Oct 1, 1996·Journal of Paediatrics and Child Health·F AlvaroM S Rice
Sep 1, 1997·Journal of Pediatric Gastroenterology and Nutrition·T MoriA Matsui
Aug 26, 1998·Journal of Clinical Gastroenterology·G BhatC Berkelhammer
Sep 29, 1999·Clinical Pediatrics·R A FarahV M Aquino
Aug 23, 2000·Leukemia & Lymphoma·M S FeliceF Sackmann-Muriel
Feb 24, 2001·Journal of Pediatric Hematology/oncology·J F KelleherA G Angelides
Aug 1, 1963·Cancer·E FREIL B THOMAS
Sep 2, 2005·Leukemia·F O SmithUNKNOWN Children's Cancer Group
Feb 21, 2008·Blood·Anja MörickeUNKNOWN German-Austrian-Swiss ALL-BFM Study Group
May 3, 2008·Seminars in Liver Disease·Robert H Squires
Dec 17, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rong-Ze YangDa-Wei Gong
May 16, 2009·Clinics in Liver Disease·Michael Krier, Aijaz Ahmed
Aug 19, 2009·Pediatric Blood & Cancer·Janice S WithycombeNita L Seibel
Citations
Aug 15, 2014·International Immunopharmacology·Min SuWei Wu
Jan 7, 2015·Saudi Journal of Biological Sciences·Mahmood RasoolAbrar Hussain
Jun 18, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Maarten J DeenenDidier Meulendijks
Oct 11, 2016·Journal of Investigative Medicine High Impact Case Reports·Marc HeincelmanDon C Rockey
Jan 17, 2017·Clinical Pharmacology and Therapeutics·Y LiuM V Relling
Jul 9, 2014·Journal of Pediatric Gastroenterology and Nutrition·Christine RivetOlivier Bernard
Jul 19, 2019·Molecular and Clinical Oncology·Ruo-Lan GuJing Yuan
Dec 9, 2017·Pediatric Blood & Cancer·Christopher C DentonEtan Orgel
Jul 23, 2021·Journal of Pediatric Gastroenterology and Nutrition·Amelie SandartJukka Vakkila
Nov 12, 2021·The Journal of Medical Investigation : JMI·Dinda Anes TunjungsariI Dewa Gede Ugrasena