Abnormal liver transaminases and conjugated hyperbilirubinemia at presentation of acute lymphoblastic leukemia

Pediatric Blood & Cancer
Idit SegalRichard A Schreiber

Abstract

Acute lymphoblastic leukemia (ALL) is the most common malignancy in childhood. While hepatitis is a well-known complication during the treatment phase of ALL, the association of abnormal liver biochemistries at initial presentation of leukemia is poorly described. The aim of this study is to examine the prevalence and assess the clinical impact of hepatitis at diagnosis in children with ALL. All children diagnosed with ALL at BC Children's Hospital between 2001 and 2006 were included. Charts were reviewed and data recorded to a computerized spreadsheet. Descriptive statistical analyses were performed. One hundred forty-seven ALL patients were identified. Over one third of patients had abnormal liver transaminase values (AST and/or ALT). Of the patients with abnormal transaminases, (52%) had ALT elevations twice the upper limit of normal. Risk factors for elevated transaminases included a high WBC count at diagnosis, older age, bulky disease, and T-cell leukemia. Conjugated hyperbilirubinemia was observed in 3.4% of subjects. Of these cases, 60% received steroids prior to induction chemotherapy and all had rapid resolution of their hyperbilirubinemia to normal levels. Elevated transaminases are common at initial presentation of ...Continue Reading

References

Aug 11, 1992·Journal of Pediatric Gastroenterology and Nutrition·E E ConwayS Mitsudo
Feb 1, 1992·Gastroenterology·M B CohenJ E Heubi
Dec 1, 1973·Clinical Pediatrics·R G McCordP J Joo
Jan 1, 1983·The American Journal of Pediatric Hematology/oncology·J M HarbE L Blank
Apr 1, 1995·Histopathology·I B ScheimbergJ D van der Walt
Nov 1, 1993·Journal of Pediatric Gastroenterology and Nutrition·R Gonzalez-VallinaP F Whitington
Jan 20, 1996·BMJ : British Medical Journal·A GoughE Elias
Jan 1, 1996·Journal of Pediatric Gastroenterology and Nutrition·D DevictorE Dussaix
Oct 1, 1996·Journal of Paediatrics and Child Health·F AlvaroM S Rice
Aug 26, 1998·Journal of Clinical Gastroenterology·G BhatC Berkelhammer
Aug 23, 2000·Leukemia & Lymphoma·M S FeliceF Sackmann-Muriel
Feb 24, 2001·Journal of Pediatric Hematology/oncology·J F KelleherA G Angelides
Aug 1, 1963·Cancer·E FREIL B THOMAS
May 3, 2008·Seminars in Liver Disease·Robert H Squires
Dec 17, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rong-Ze YangDa-Wei Gong
May 16, 2009·Clinics in Liver Disease·Michael Krier, Aijaz Ahmed

❮ Previous
Next ❯

Citations

Aug 15, 2014·International Immunopharmacology·Min SuWei Wu
Jun 18, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Maarten J DeenenDidier Meulendijks
Oct 11, 2016·Journal of Investigative Medicine High Impact Case Reports·Marc HeincelmanDon C Rockey
Jul 9, 2014·Journal of Pediatric Gastroenterology and Nutrition·Christine RivetOlivier Bernard
Jul 19, 2019·Molecular and Clinical Oncology·Ruo-Lan GuJing Yuan
Jul 23, 2021·Journal of Pediatric Gastroenterology and Nutrition·Amelie SandartJukka Vakkila
Nov 12, 2021·The Journal of Medical Investigation : JMI·Dinda Anes TunjungsariI Dewa Gede Ugrasena

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Related Papers

The American Journal of Gastroenterology
Flavia D MendesKeith D Lindor
Current Treatment Options in Gastroenterology
K N Lazaridis, Keith D Lindor
© 2021 Meta ULC. All rights reserved