Abnormal maternal behaviour and growth retardation associated with loss of the imprinted gene Mest

Nature Genetics
L LefebvreM A Surani


Mest (also known as Peg1), an imprinted gene expressed only from the paternal allele during development, was disrupted by gene targeting in embryonic stem (ES) cells. The targeted mutation is imprinted and reversibly silenced by passage through the female germ line. Paternal transmission activates the targeted allele and causes embryonic growth retardation associated with reduced postnatal survival rates in mutant progeny. More significantly, Mest-deficient females show abnormal maternal behaviour and impaired placentophagia, a distinctive mammalian behaviour. Our results provide evidence for the involvement of an imprinted gene in the control of adult behaviour.


Jun 22, 2000·Molecular Reproduction and Development·L B KoskiR J Etches
Jul 19, 2002·Journal of Cellular Physiology·Benjamin Tycko, Ian M Morison
Dec 21, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·S ApostolidouG E Moore
Apr 30, 2005·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Sylvie CroteauAnna K Naumova
Aug 27, 2013·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Claire L Dent, Anthony R Isles
Jun 19, 2013·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A C VidalC Hoyo
Jul 4, 2012·The Journal of Physiological Sciences : JPS·Yoshito KadotaShinya Suzuki
Jun 19, 2012·Clinical Epigenetics·Martina Paulsen
Jun 28, 2002·Nature·Benjamin Tycko, Argiris Efstratiadis
Oct 23, 2008·European Journal of Human Genetics : EJHG·Deniz KanberBernhard Horsthemke
Jul 6, 2012·European Journal of Human Genetics : EJHG·John D HuntrissHelen M Picton
Apr 24, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A C VidalC Hoyo
Mar 12, 2005·Nature Reviews. Genetics·Gene E RobinsonCharles W Whitfield
Apr 5, 2003·Kidney International·Yashpal S KanwarJon W Lomasney
Aug 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Kevin D Broad, E B Keverne
Jan 17, 2008·The Australian and New Zealand Journal of Psychiatry·Selma Stuffrein-RobertsMartin A Kennedy
Mar 11, 2003·Cloning and Stem Cells·A OguraF Ishino
Sep 1, 2005·Thyroid : Official Journal of the American Thyroid Association·Arturo Hernandez
Oct 22, 2011·Genome Biology and Evolution·Shunsuke SuzukiMarilyn B Renfree
Oct 21, 2010·Human Reproduction Update·Ewka C M NelissenJohannes L H Evers
Oct 12, 2012·Human Reproduction Update·Ellen AnckaertJohan Smitz
Oct 13, 2001·Schizophrenia Bulletin·D Malaspina
Dec 17, 2008·Biology of Reproduction·Yong ChengKeith E Latham
Jul 23, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Larissa NikonovaLeslie P Kozak
Apr 6, 2002·Proceedings. Biological Sciences·Anthony R IslesNicholas D Allen
Jul 20, 2012·Proceedings. Biological Sciences·Joël Meunier, Mathias Kölliker
Nov 23, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Anthony R IslesLawrence S Wilkinson
Nov 21, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·E B Keverne
May 18, 2011·Cold Spring Harbor Perspectives in Biology·Marisa S Bartolomei, Anne C Ferguson-Smith


Jan 1, 1991·Neuroscience and Biobehavioral Reviews·M B Kristal
Feb 22, 1991·Cell·T M DeChiaraArgiris Efstratiadis
Feb 1, 1991·Trends in Genetics : TIG·T Moore, D Haig
Aug 1, 1988·Journal of Medical Genetics·M A Patton
Jan 1, 1986·Physiology & Behavior·J R FranzM B Kristal
Nov 7, 1995·Proceedings of the National Academy of Sciences of the United States of America·Nicholas D AllenE B Keverne
Sep 1, 1995·Nature Genetics·Tomoko Kaneko-ishinoM A Surani
Mar 27, 1995·American Journal of Medical Genetics·C A WilliamsE M Whidden
Apr 1, 1995·Human Molecular Genetics·D KotzotM Hergersberg
Jan 1, 1994·Developmental Genetics·Reinald Fundele, M A Surani
Jun 1, 1994·Acta Paediatrica. Supplement·M Numan
May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·P MountfordA Smith
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A NagyJ C Roder
Nov 1, 1995·Journal of Medical Genetics·S LangloisD K Kalousek
Jun 1, 1996·Current Opinion in Cell Biology·R M John, M A Surani
Jan 1, 1996·Neuroscience and Biobehavioral Reviews·L L Bernardis, L L Bellinger
Jan 1, 1997·Journal of Medical Genetics·M A PreeceG E Moore
May 1, 1997·Human Molecular Genetics·S KobayashiF Ishino
Jul 1, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·B M CattanachJ Jones
Sep 25, 1997·Human Molecular Genetics·Louis LefebvreM A Surani
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·N MiyoshiF Ishino

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