Abnormal mechanisms of antisaccade generation in schizophrenia patients and unaffected biological relatives of schizophrenia patients.

Psychophysiology
Seung Suk KangScott R Sponheim

Abstract

Although errant saccadic eye movements may mark genetic factors in schizophrenia, little is known about abnormal brain activity that precedes saccades in individuals with genetic liability for schizophrenia. We investigated electrophysiological activity preceding prosaccades and antisaccades in schizophrenia patients, first-degree biological relatives of schizophrenia patients, and control subjects. Prior to antisaccades, patients had reduced potentials over lateral prefrontal cortex. Smaller potentials were associated with worse antisaccade performance. Relatives also exhibited reduced pre-saccadic potentials over lateral frontal cortex but additionally had reduced potentials over parietal cortex. Both patients and relatives tended toward increased activity over orbital frontal cortex prior to saccades. Results are consistent with lateral prefrontal dysfunction marking genetic liability for schizophrenia and underlying deficient saccadic control.

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Citations

Sep 17, 2013·PloS One·Simon SchwabAndreas Altorfer
Mar 10, 2016·Harvard Review of Psychiatry·Emily M OwensCarrie E Bearden
Nov 19, 2011·Psychophysiology·Désirée S AichertUlrich Ettinger
Mar 12, 2015·Frontiers in Behavioral Neuroscience·Simon SchwabAndreas Altorfer
Oct 19, 2013·Brain Structure & Function·Edna C CieslikSimon B Eickhoff
Oct 27, 2017·The Spanish Journal of Psychology·Anna V KirenskayaVladimir Yu Novototsky-Vlasov
Mar 1, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Vassilis Cutsuridis

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