Abnormal Morphology of Blood Vessels in Erythematous Skin From Atopic Dermatitis Patients

The American Journal of Dermatopathology
Moe TsutsumiMitsuhiro Denda

Abstract

Previous studies suggest that altered peripheral blood circulation might be associated with erythema or inflammation in atopic dermatitis (AD) patients. However, the overall structure of blood vessels and capillaries in AD skin is poorly understood because most studies have involved light-microscopic observation of thin skin sections. In the present study, we compared the 3-dimensional structures of peripheral blood vessels of healthy subjects and AD patients in detail by means of 2-photon microscopy. In skin from healthy subjects, superficial vascular plexus and capillaries originating from flexous blood vessels were observed. However, skin from AD patients contained thickened, flexuous blood vessels, which might be associated with increased blood flow, in both erythematous and nonlesional areas. However, patients with lichenification did not display these morphological changes. Bifurcation of vessels was not observed in either erythematous or lichenification lesions. These results might be helpful for developing new clinical strategies to treat erythema in AD patients.

References

Feb 4, 2006·Archives of Dermatological Research·Yan ZhangEishin Morita
Jul 4, 2006·The Journal of Allergy and Clinical Immunology·Martin SteinhoffStefan W Schneider
Feb 23, 2013·Journal of Allergy·Silvana ZgraggenMichael Detmar

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Citations

Aug 17, 2018·Current Opinion in Allergy and Clinical Immunology·Joachim W FluhrRazvigor Darlenski
Aug 18, 2018·Pigment Cell & Melanoma Research·Takako ShibataHee Young Kang
Jun 6, 2021·Clinical and Experimental Dermatology·S Arslan UkuE Inan Yuksel

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Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

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