Abnormal myocardial and coronary vasculature development in experimental hypoxia

The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology
O NankaDavid Sedmera

Abstract

Oxygen availability is one of the necessary prerequisites for normal embryonic development. In our previous study we found that quail embryos incubated under hypoxic conditions (16% O(2)) die at embryonic day (ED) 9 with signs of heart failure. By ED4 and ED6 we found thinner ventricular wall and increased capillary density. We thus hypothesized that the cause of death would lie in severe myocardial and coronary maldevelopment. ED6 and 7 hypoxic hearts had thinner ventricular wall, especially left. There was a simultaneous increase in capillary density, most pronounced in the interventricular septum. This site corresponds to an area of tissue hypoxia and ensuing increased angiogenesis, and also formation of ventricular conduction system. Hypoxia had a positive effect on normal sequence of maturation of the conduction system evaluated by optical mapping at ED7. In sections from ED9 hypoxic hearts we found, in addition to thinner ventricular walls, irregularities in development of coronary tree (missing coronary ostia, absence of one coronary artery, and irregular arterial wall). This deficiency was due to decreased myocyte proliferation rather than to increased apoptosis. By Indian ink injection through the left ventricle we fou...Continue Reading

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Citations

Mar 4, 2011·Cardiovascular Research·David Sedmera
Jun 29, 2012·Cardiovascular Research·Barbora SankovaDavid Sedmera
May 31, 2014·Canadian Journal of Physiology and Pharmacology·Bohuslav OstadalDavid Sedmera
Feb 10, 2016·Differentiation; Research in Biological Diversity·Tim P KelderMonique R M Jongbloed
Sep 1, 2014·Developmental Biology·Laura DyerCam Patterson
Sep 25, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jamie WikenheiserMichiko Watanabe
Jan 26, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Shi GuMichiko Watanabe
Jun 14, 2012·Birth Defects Research. Part C, Embryo Today : Reviews·Wolfgang J Weninger, Stefan H Geyer
Nov 5, 2014·Acta Physiologica·D SedmeraE Raddatz
Feb 7, 2013·Developmental Biology·Jiayi TaoMichiko Watanabe
Jun 24, 2014·Progress in Biophysics and Molecular Biology·Frantisek VostarekDavid Sedmera
Nov 27, 2014·Frontiers in Physiology·Kersti K LinaskNathalie J M Bravo-Valenzuela
Apr 17, 2016·Acta Physiologica·F VostarekD Sedmera
May 18, 2018·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Hana KolesováDavid Sedmera
Aug 29, 2018·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Rebecca Vicente SteijnOndrej Nanka
Oct 12, 2018·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Alena KvasilovaDavid Sedmera
May 26, 2017·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Zivorad PesevskiDavid Sedmera
Mar 17, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Barbora SankovaDavid Sedmera
Sep 13, 2020·Scientific Reports·Maryse Lapierre-LandryMichael W Jenkins
Mar 4, 2021·Poultry Science·Amit HaronShelly Druyan
Mar 6, 2021·IScience·Ivan Menendez-MontesSilvia Martin-Puig
May 14, 2021·IScience·Hana KolesováDavid Sedmera

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