Abnormal myofiber morphology and limb dysfunction in claudication

The Journal of Surgical Research
Panagiotis KoutakisIraklis I Pipinos

Abstract

Peripheral artery disease (PAD), which affects an estimated 27 million people in Europe and North America, is caused by atherosclerotic plaques that limit blood flow to the legs. Chronic, repeated ischemia in the lower leg muscles of PAD patients is associated with loss of normal myofiber morphology and myofiber degradation. In this study, we tested the hypothesis that myofiber morphometrics of PAD calf muscle are significantly different from normal calf muscle and correlate with reduced calf muscle strength and walking performance. Gastrocnemius biopsies were collected from 154 PAD patients (Fontaine stage II) and 85 control subjects. Morphometric parameters of gastrocnemius fibers were determined and evaluated for associations with walking distances and calf muscle strength. Compared with control myofibers, PAD myofiber cross-sectional area, major and minor axes, equivalent diameter, perimeter, solidity, and density were significantly decreased (P < 0.005), whereas roundness was significantly increased (P < 0.005). Myofiber morphometric parameters correlated with walking distances and calf muscle strength. Multiple regression analyses demonstrated myofiber cross-sectional area, roundness, and solidity as the best predictors o...Continue Reading

References

Feb 1, 1992·Medicine and Science in Sports and Exercise·A W GardnerL K Smith
Aug 1, 1989·European Journal of Vascular Surgery·B HedbergM Sjöström
Jan 1, 1968·Scandinavian Journal of Clinical and Laboratory Investigation·B Pernow, S Zetterquist
Apr 29, 2003·Exercise and Sport Sciences Reviews·Robert J Bloch, Hugo Gonzalez-Serratos
Feb 26, 2004·Journal of Vascular Surgery·Mary McGrae McDermottJoseph R Schneider
Sep 1, 2004·Journal of Vascular Surgery·Timothy A BauerWilliam R Hiatt
Jul 4, 2006·Free Radical Biology & Medicine·Iraklis I PipinosStephen L Dodd
Dec 5, 2006·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·L NorgrenKenneth Rosenfield
Jan 16, 2007·Journal of Vascular Surgery·L NorgrenUNKNOWN TASC II Working Group
Sep 11, 2007·Journal of Vascular Surgery·Melissa M Scott-PandorfIraklis I Pipinos
Nov 27, 2007·Journal of Vascular Nursing : Official Publication of the Society for Peripheral Vascular Nursing·Marge Lovell
Nov 26, 2008·Journal of Vascular Surgery·Rolando CelisJason M Johanning
Oct 20, 2009·Journal of Vascular Surgery·Panagiotis KoutakisJason M Johanning
Jul 14, 2010·Journal of Biomedicine & Biotechnology·Joseph W SangerJean M Sanger
Jul 31, 2010·Journal of Vascular Surgery·Panagiotis KoutakisIraklis I Pipinos
Aug 25, 2010·Annual Review of Medicine·Shontelle DodsonMitchell S Steiner
Nov 3, 2010·Circulation·Gregorio BrevettiWilliam R Hiatt
Jan 5, 2012·Circulation·Véronique L RogerUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Mar 24, 2012·Journal of the American College of Cardiology·Mary M McDermottLuigi Ferrucci
May 12, 2012·Cardiology Research and Practice·Rolf SpirigSidney Shaw
Aug 30, 2012·The Journal of Pharmacology and Experimental Therapeutics·Marco Brotto, Eduardo L Abreu
Feb 19, 2013·Neuropathology and Applied Neurobiology·M FaninC Angelini
May 31, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kim CluffGeorge P Casale
Jun 7, 2013·Aging Clinical and Experimental Research·Christian BarillaroFrancesco Landi
Sep 27, 2013·Journal of Translational Medicine·Dustin J WeissIraklis I Pipinos
Jan 13, 2015·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Panagiotis KoutakisIraklis I Pipinos

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Citations

May 21, 2015·International Journal of Molecular Sciences·Smriti Murali KrishnaJonathan Golledge
Sep 14, 2016·The Journal of Surgical Research·Hassan AlbadawiMichael T Watkins
Oct 4, 2016·Journal of Vascular Surgery·Chandler A LongLuke P Brewster
Jan 27, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Naomi M Hamburg, Mark A Creager
Jul 12, 2017·IEEE Transactions on Bio-medical Engineering·Kim CluffJeremy Patterson
Jun 5, 2019·Journal of Applied Physiology·Kyoungrae KimBruno T Roseguini
Dec 27, 2017·The Cochrane Database of Systematic Reviews·Risha LaneGillian C Leng
Jul 11, 2020·Journal of Cachexia, Sarcopenia and Muscle·Mégane PizzimentiBernard Geny
Sep 18, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Mary M McDermottRobert Sufit
Aug 25, 2020·Translational Research : the Journal of Laboratory and Clinical Medicine·George P CasaleIraklis I Pipinos
Jan 28, 2020·The Journal of Surgical Research·Yue GaoMark A Carlson
May 30, 2021·Journal of Cardiovascular Translational Research·Juline N DeppenRebecca D Levit
Jun 11, 2021·Circulation Research·Mary M McDermottLuigi Ferrucci

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