Abnormal N-acetylaspartate in hippocampus and anterior cingulate in posttraumatic stress disorder.

Psychiatry Research
N SchuffM W Weiner

Abstract

Magnetic resonance spectroscopic imaging (MRSI) studies suggest hippocampal abnormalities in posttraumatic stress disorder (PTSD), whereas findings of volume deficits in the hippocampus, as revealed with magnetic resonance imaging (MRI), have been inconsistent. Co-morbidities of PTSD, notably alcohol abuse, may have contributed to the inconsistency. The objective was to determine whether volumetric and metabolic abnormalities in the hippocampus and other brain regions are present in PTSD, independent of alcohol abuse. Four groups of subjects, PTSD patients with (n=28) and without (n=27) alcohol abuse and subjects negative for PTSD with (n=23) and without (n=26) alcohol abuse, were enrolled in this observational MRI and MRSI study of structural and metabolic brain abnormalities in PTSD. PTSD was associated with reduced N-acetylaspartate (NAA) in both the left and right hippocampus, though only when normalized to creatine levels in the absence of significant hippocampal volume reduction. Furthermore, PTSD was associated with reduced NAA in the right anterior cingulate cortex regardless of creatine. NAA appears to be a more sensitive marker for neuronal abnormality in PTSD than brain volume. The alteration in the anterior cingulat...Continue Reading

References

Aug 11, 1992·Archives of General Psychiatry·J B WilliamsB Rounsaville
Jan 1, 1987·Annals of the New York Academy of Sciences·P A Bottomley
Jan 1, 1995·Journal of Traumatic Stress·D D BlakeT M Keane
Jul 1, 1997·Psychological Medicine·M B SteinB McClarty
Jul 11, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T W FreemanR A Komoroski
Jun 1, 1999·Biological Psychiatry·M D De BellisN D Ryan
Oct 4, 2000·Archives of General Psychiatry·R M Sapolsky
Apr 27, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·N SchuffM W Weiner
Aug 2, 2001·The American Journal of Psychiatry·O BonneA Y Shalev
Dec 26, 2001·Biological Psychiatry·L M ShinS L Rauch
Jun 1, 2002·Alzheimer Disease and Associated Disorders·Yuan-Yu HsuMichael W Weiner
Jul 13, 2002·Biological Psychiatry·Gerardo VillarrealWilliam M Brooks
Oct 16, 2002·Nature Neuroscience·Mark W GilbertsonRoger K Pitman
Dec 4, 2002·Biological Psychiatry·Christine Fennema-NotestineTerry L Jernigan
Jul 10, 2003·Psychiatry Research·P Mohanakrishnan MenonVincent Liberto
Jul 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·H YamasueN Kato
Dec 11, 2003·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Dawson W HedgesErin D Bigler
Sep 17, 2005·Biological Psychiatry·Steven H WoodwardStephan Eliez
Dec 20, 2005·Psychiatry Research·Thomas FreemanRichard A Komoroski
May 30, 2006·Neuroscience and Biobehavioral Reviews·Anke KarlAnnett Werner

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Citations

Apr 20, 2014·Psychiatry Research·Linda L ChaoThomas C Neylan
Oct 30, 2013·Disease Markers·Ulrike SchmidtCarsten T Wotjak
Jul 25, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lisa M Shin, Israel Liberzon
Jan 28, 2010·Journal of Rehabilitation Research and Development·Robert W Van BovenMichael W Weiner
Mar 8, 2013·PloS One·Joseph J GallagherRussell E Jacobs
Mar 11, 2016·MMW Fortschritte der Medizin·Harald C Traue, Lucia Jerg-Bretzke
Apr 3, 2012·Neuroscience and Biobehavioral Reviews·Patricia J Allen
Jun 21, 2011·Psychiatry Research·Valerie A CardenasMichael W Weiner
Oct 5, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Jiaojie HuiGavin P Reynolds
Aug 7, 2010·Psychiatry Research·Lionel LandréWissam El Hage
Sep 11, 2009·Journal of Traumatic Stress·Lisa M Shin, Kathryn Handwerger
Jun 14, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Brian S MohlenhoffThomas C Neylan
Jun 14, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Michael W WeinerUNKNOWN Department of Defense Alzheimer's Disease Neuroimaging Initiative
Aug 15, 2014·Journal of Neurology·Maria WostrackYu-Mi Ryang
Apr 26, 2016·Experimental Neurology·Lauren A M LeboisKerry J Ressler
Apr 5, 2017·Psychological Medicine·S WilsonW G Iacono
Jan 6, 2009·Current Opinion in Psychiatry·Cristian DamsaJoanna Moussally
Oct 11, 2012·Nature Reviews. Neuroscience·Roger K PitmanIsrael Liberzon
Feb 15, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Isabelle M RossoJ Eric Jensen
Mar 18, 2016·Physiological Reviews·Ivan IzquierdoJociane C Myskiw
Oct 11, 2017·Harvard Review of Psychiatry·Mark W MillerDanielle R Miller
May 23, 2019·Frontiers in Behavioral Neuroscience·Veronica M PiggottShane A Perrine
Aug 2, 2017·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Michael W WeinerUNKNOWN Department of Defense Alzheimer's Disease Neuroimaging Initiative
Jul 17, 2018·NeuroImage. Clinical·Abdalla Z MohamedUNKNOWN Department of Defense Alzheimer's Disease Neuroimaging Initiative
Nov 11, 2020·Journal of Psychiatric Research·J Douglas BremnerViola Vaccarino

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