Abnormal Neural Network of Primary Insomnia: Evidence from Spatial Working Memory Task fMRI

European Neurology
Yongli LiDapeng Shi

Abstract

Contemporary functional MRI (fMRI) methods can provide a wealth of information about the neural mechanisms associated with primary insomnia (PI), which centrally involve neural network circuits related to spatial working memory. A total of 30 participants diagnosed with PI and without atypical brain anatomy were selected along with 30 age- and gender-matched healthy controls. Subjects were administered the Pittsburgh Sleep Quality Index (PSQI), Hamilton Rating Scale for Depression and clinical assessments of spatial working memory, followed by an MRI scan and fMRI in spatial memory task state. Statistically significant differences between PSQI and spatial working memory were observed between PI patients and controls (p < 0.01). Activation of neural networks related to spatial memory task state in the PI group was observed at the left temporal lobe, left occipital lobe and right frontal lobe. Lower levels of activation were observed in the left parahippocampal gyrus, right parahippocampal gyrus, bilateral temporal cortex, frontal cortex and superior parietal lobule. Participants with PI exhibited characteristic abnormalities in the neural network connectivity related to spatial working memory. These results may be indicative of ...Continue Reading

Citations

Oct 6, 2017·Sleep & Breathing = Schlaf & Atmung·Young-Don SonSeung-Gul Kang
Feb 23, 2019·Sleep·Charlotte MuscarellaEva Van den Bussche
May 10, 2020·JNCI Cancer Spectrum·Ingrid Tonning OlssonTara M Brinkman
Mar 11, 2021·Nature and Science of Sleep·Arun VenkataramanGiovanni Schifitto
Apr 11, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kexin HuangLiyu Huang
Dec 1, 2021·Brain Imaging and Behavior·Youling BaiHuazhan Yin

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