PMID: 2760232Jul 1, 1989

Abnormal platelet aggregation in patients with Raynaud's phenomenon

Journal of Clinical Pathology
M L Biondi, B Marasini

Abstract

Platelet aggregation in vitro to several aggregating agents (serotonin (5-HT), adenosine diphosphate, adrenaline and collagen) was studied in 16 patients with primary and secondary Raynaud's phenomenon and compared with that in 13 normal volunteers. Platelets from patients with Raynaud's phenomenon had significantly greater responses to all the 5-HT concentrations tested (p less than 0.001 for 10 microM; p less than 0.01 for 1 microM; p less than 0.05 for 0.1 microM; p less than 0.02 for 0.025 microM) and to low doses of adenosine diphosphate (p less than 0.01 for 1 microM; p less than 0.02 for 0.5 microM) but normal responses to collagen, adrenaline, and high doses of adenosine diphosphate. Patients with secondary Raynaud's phenomenon were significantly more hypersensitive to 0.5 microM adenosine diphosphate than patients with primary Raynaud's phenomenon. In patients with secondary Raynaud's phenomenon there was a significant correlation between the extent of 5-HT aggregation and the duration of the disease. The finding that platelets from patients with Raynaud's phenomenon have enhanced responses to 5-HT and adenosine diphosphate, but normal responses to adrenaline and collagen, is consistent with a role for 5-HT in this dis...Continue Reading

References

Jul 1, 1976·The British Journal of Dermatology·R K WinkelmannR L Linscheid
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Jan 1, 1988·European Journal of Clinical Pharmacology·B MarasiniA Agostoni
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Citations

Oct 30, 1998·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·E P TurtonR C Kester
Apr 18, 1991·The New England Journal of Medicine·L GarlandH Saba
Feb 1, 1991·Journal of Clinical Pathology·G Slutsker
Apr 1, 1994·Postgraduate Medical Journal·P LagunaM Moya
Apr 1, 1994·Postgraduate Medical Journal·P S Sarma
Nov 1, 1992·Neurosurgery·F G MoserJ Llana
Dec 2, 2010·Internal Medicine Journal·L PolidoroG Properzi
Nov 1, 1991·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·D GreensteinR C Kester
May 15, 2003·Arthritis and Rheumatism·Maureen D Mayes

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