Abnormal positioning of granule cells alters afferent fiber distribution in the mouse fascia dentata: morphologic evidence from reeler, apolipoprotein E receptor 2-, and very low density lipoprotein receptor knockout mice

The Journal of Comparative Neurology
Carl GebhardtThomas Deller

Abstract

The fascia dentata of the hippocampal formation is characterized by the nonoverlapping and lamina-specific termination of afferent fibers: entorhinal fibers terminate in the outer molecular layer and commissural/associational fibers terminate in the inner molecular layer. It has been proposed that this fiber lamination depends on the presence of the correct postsynaptic partner at the time of fiber ingrowth during development. Pioneer neurons that guide afferent fibers to their correct layers as well as signals located on granule cells have both been implicated. To study the role of granule cells for the lamina-specific ingrowth of afferents, the cyto- and fiberarchitecture of three mouse mutants (very low density lipoprotein receptor knockout mouse, apolipoprotein E receptor 2 knockout mouse, and reeler mouse) that show different degrees of granule cell migration defects were analyzed. Anterograde tracing with Phaseolus vulgaris-leucoagglutinin was used to visualize the afferent fiber systems, and immunohistochemistry was used to determine the position of their putative target cells. In controls, granule cells are packed in a single layer. This laminar organization is mildly altered in very low density lipoprotein receptor kno...Continue Reading

References

Jun 1, 1979·The Journal of Comparative Neurology·B B Stanfield, W M Cowan
Jun 1, 1979·The Journal of Comparative Neurology·B B Stanfield, W M Cowan
Jun 1, 1979·The Journal of Comparative Neurology·B B StanfieldW M Cowan
Oct 1, 1992·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·M Frotscher
May 13, 1982·Brain Research·K G BaimbridgeC O Parkes
Aug 29, 1995·Proceedings of the National Academy of Sciences of the United States of America·P K FrykmanJ Herz
Jan 1, 1993·Experimental Brain Research·D von HaeblerU Heinemann
Jul 1, 1996·Brain Research. Molecular Brain Research·G D'ArcangeloT Curran
Nov 15, 1996·Science·M Tessier-Lavigne, C S Goodman
Mar 14, 1998·Trends in Neurosciences·M Marín-Padilla
Jun 26, 1998·Brain Research. Brain Research Reviews·H SupèrH B Uylings
Nov 26, 1999·Neuron·G D'ArcangeloT Curran
Jul 27, 2000·Annals of the New York Academy of Sciences·K CeranikM Frotscher
Feb 13, 2001·Trends in Neurosciences·T Skutella, R Nitsch

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Citations

Jul 28, 2009·Experimental Brain Research·Carola A Haas, Michael Frotscher
Apr 28, 2009·Journal of Neural Transmission·Michael FrotscherShanting Zhao
Mar 20, 2003·Brain Research. Developmental Brain Research·Shunsuke SakakibaraToshio Terashima
Oct 1, 2004·Molecular and Cellular Biology·Tiia Pönniö, Orla M Conneely
Sep 23, 2014·BMC Neuroscience·Jorge A LariosMaria-Paz Marzolo
Jun 9, 2014·Cardiovascular Research·Cecilia VitaliLaura Calabresi
Jan 18, 2003·The Journal of Comparative Neurology·Alexander NikonenkoMelitta Schachner
Dec 23, 2006·NeuroImage·Alexandra BadeaWilliam C Wetsel
May 1, 2008·Hippocampus·Yanling Wang, Scott C Baraban
Aug 23, 2005·Brain Research. Brain Research Reviews·Albert Martínez, Eduardo Soriano
Mar 14, 2014·Frontiers in Cellular Neuroscience·Richard BelvindrahFiona Francis
Jul 29, 2004·The Journal of Comparative Neurology·Domenico Del TurcoThomas Deller
Mar 18, 2006·Nature Reviews. Neuroscience·Eckart FörsterMichael Frotscher
Dec 7, 2006·Developmental Neuroscience·Daisuke MuraokaToshio Terashima
Oct 2, 2004·Development·Shanting ZhaoMichael Frotscher

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