PMID: 1201146Nov 1, 1975Paper

Abnormal post-heparin lipolytic activity in obesity. A preliminary note

Atherosclerosis
B W GladJ C Reading

Abstract

Published data have suggested that hypertriglyceridemia in obesity may result from the combination of hepatic overproduction and diminished removal of triglyceride-rich lipoproteins. Diminished catabolism might be expected if tissue lipoprotein lipase activity were decreased, a finding which has been reported in biopsies of adipose tissue from obese subjects. Abnormalities in heparin-released triglyceride lipase activity (PHLA) in obesity have not been reported, however. We have examined the possibility that methods for the measurement of PHLA might have failed to reveal such a defect because of the disproportionality between plasma volume and increasing body mass in obesity. Since it is usual to administer heparin on the basis of body weight, higher plasma heparin levels would be achieved in obese individuals. We performed standard PHLA assays in lean and obese volunteers. In the obese, heparin levels were consistently higher than in lean individuals although PHLA values were similar in both. Thus, PHLA in obesity appeared to be inappropriate for the heparin levels attained in plasma. Pharmacokinetic studies suggest that a decrease in PHLA available for release by heparin rather than heparin insensitivity underlies this phenom...Continue Reading

References

Apr 8, 1974·Biochemical and Biophysical Research Communications·P J Dolphin, D Rubinstein
Jul 25, 1974·The New England Journal of Medicine·G V Mann
Oct 1, 1969·Annals of Internal Medicine·W M Bortz
Jan 1, 1971·Annual Review of Medicine·E A SimsL B Salans
Oct 8, 1965·Annals of the New York Academy of Sciences·M J Albrink, J W Meigs
Feb 1, 1971·The British Journal of Surgery·C M MorrisJ M Ham
Sep 1, 1968·The American Journal of Clinical Nutrition·S FordH C Knowles
Dec 1, 1968·Metabolism: Clinical and Experimental·P J Nestel, H M Whyte
May 1, 1969·Clinical Pharmacology and Therapeutics·J W EstesE Krüger-Thiemer
Nov 1, 1965·The Journal of Clinical Investigation·G M ReavenJ W Farquhar

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Citations

Jan 1, 1977·Acta Medica Scandinavica·M R Taskinen, E A Nikkilä

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