Abnormal reward prediction-error signalling in antipsychotic naive individuals with first-episode psychosis or clinical risk for psychosis.

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Anna O ErmakovaGraham K Murray

Abstract

Ongoing research suggests preliminary, though not entirely consistent, evidence of neural abnormalities in signalling prediction errors in schizophrenia. Supporting theories suggest mechanistic links between the disruption of these processes and the generation of psychotic symptoms. However, it is unknown at what stage in the pathogenesis of psychosis these impairments in prediction-error signalling develop. One major confound in prior studies is the use of medicated patients with strongly varying disease durations. Our study aims to investigate the involvement of the meso-cortico-striatal circuitry during reward prediction-error signalling in earliest stages of psychosis. We studied patients with first-episode psychosis (FEP) and help-seeking individuals at-risk for psychosis due to sub-threshold prodromal psychotic symptoms. Patients with either FEP (n = 14), or at-risk for developing psychosis (n = 30), and healthy volunteers (n = 39) performed a reinforcement learning task during fMRI scanning. ANOVA revealed significant (p < 0.05 family-wise error corrected) prediction-error signalling differences between groups in the dopaminergic midbrain and right middle frontal gyrus (dorsolateral prefrontal cortex, DLPFC). FEP patient...Continue Reading

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Citations

May 7, 2019·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Michael F GreenJunghee Lee
Jul 5, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nicole R KarcherJohn G Kerns
Apr 23, 2020·Schizophrenia Bulletin·Teresa KatthagenFlorian Schlagenhauf
Apr 2, 2019·Computational Psychiatry·Anna O ErmakovaGraham K Murray
Jul 14, 2020·Frontiers in Neuroscience·Kyna-Anne ConnJames P Kesby
Mar 18, 2020·NeuroImage. Clinical·David M ColeKlaas E Stephan
May 1, 2021·Journal of Clinical Medicine·Lee Wei Lim, Luca Aquili
Oct 1, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Samuel J MillardMelissa J Sharpe

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