Abnormal sensorimotor control, but intact force field adaptation, in multiple sclerosis subjects with no clinical disability

Multiple Sclerosis : Clinical and Laboratory Research
Maura CasadioClaudio Solaro

Abstract

In MS subjects with no clinical disability, we assessed sensorimotor organization and their ability to adapt to an unfamiliar dynamical environment. Eleven MS subjects performed reaching movements while a robot generated a speed-dependent force field. Control and adaptation performance were compared with that of an equal number of control subjects. During a familiarization phase, when the robot generated no forces, the movements of MS subjects were more curved, displayed greater and more variable directional errors and a longer deceleration phase. During the force field phase, both MS and control subjects gradually learned to predict the robot-generated forces. The rates of adaptation were similar, but MS subjects showed a greater variability in responding to the force field. These results suggest that MS subjects have a preserved capability of learning to predict the effects of the forces, but make greater errors when actually using such predictions to generate movements. Inaccurate motor commands are then compensated later in the movement through an extra amount of sensory-based corrections. This indicates that early in the disease MS subjects have intact adaptive capabilities, but impaired movement execution.

References

Oct 1, 1984·Neurology·J C SipeM B Oldstone
Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Oct 26, 2000·Nature·K A Thoroughman, R Shadmehr
Aug 10, 2001·Journal of Neurophysiology·R A ScheidtF A Mussa-Ivaldi
May 3, 2002·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A R LangkildeH B W Larsson
Jan 11, 2003·Journal of Neurophysiology·Sarah E Criscimagna-HemmingerReza Shadmehr
Sep 19, 2003·Journal of Neurophysiology·Matthias MaschkeJürgen Konczak
Oct 28, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jörn DiedrichsenReza Shadmehr
Oct 29, 2005·Journal of Neurology·Massimo Filippi, Maria Assunta Rocca
Apr 22, 2006·Journal of the Neurological Sciences·Caterina MaineroCarlo Pozzilli
Jul 19, 2006·Journal of Rehabilitation Research and Development·Gerdienke B PrangeMaarten J Ijzerman
Nov 8, 2006·Multiple Sclerosis : Clinical and Laboratory Research·C L MartinM P Galea
Mar 14, 2007·Neurorehabilitation and Neural Repair·Letizia LeocaniGiancarlo Comi
Apr 12, 2007·Neurological Research·Jun Wang, Daniel B Hier
Apr 19, 2007·Multiple Sclerosis : Clinical and Laboratory Research·C SolaroV Sanguineti

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Citations

Feb 23, 2010·Experimental Brain Research·Maura CasadioPietro Morasso
Jul 3, 2013·Experimental Brain Research·Andrea TacchinoGiampaolo Brichetto
Sep 14, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Valentina TomassiniPaul M Matthews
Jul 31, 2010·Journal of Neuroengineering and Rehabilitation·Elena VergaroVittorio Sanguineti
May 24, 2011·Journal of Neuroengineering and Rehabilitation·Lorenzo MasiaPaolo Cappa
Jan 26, 2011·Journal of Neuroengineering and Rehabilitation·Domien GijbelsPeter Feys
Apr 22, 2014·Journal of Neuroengineering and Rehabilitation·Ilaria CarpinellaMaurizio Ferrarin
Oct 7, 2015·Experimental Brain Research·S Y Schaefer, C R Hengge
May 25, 2012·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Ilaria CarpinellaMaurizio Ferrarin
Apr 26, 2012·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Maura Casadio, Vittorio Sanguineti
Mar 31, 2015·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Patrica SampsonAnn-Marie Hughes
Apr 23, 2015·Journal of Neuroengineering and Rehabilitation·Marco GermanottaEnrico Castelli
Jun 8, 2017·Neurorehabilitation and Neural Repair·Kayla McGowanDaniel S Marigold
Dec 26, 2015·Neurorehabilitation and Neural Repair·Geetanjali GeraFay B Horak
Jan 24, 2018·Human Brain Mapping·Riccardo IandoloMatilde Inglese
Dec 7, 2019·Experimental Brain Research·Laura PellegrinoMaura Casadio
May 12, 2020·Annals of Rehabilitation Medicine·Wioletta PawlukowskaPrzemysław Nowacki
Dec 3, 2016·Journal of Back and Musculoskeletal Rehabilitation·Bilge KaraEgemen İdıman
May 17, 2017·NeuroRehabilitation·Christophe Duret, Stefano Mazzoleni
Oct 18, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Carine NguemeniDaniel Zeller
Sep 19, 2021·Scientific Reports·Laura PellegrinoMaura Casadio

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