Abnormal sleep duration associated with hastened depressive recurrence in bipolar disorder

Journal of Affective Disorders
Anda GershonTerence A Ketter

Abstract

Abnormal sleep duration (ASD, <6 or ≥9h) is common in bipolar disorder (BD), and often persists beyond acute mood episodes. Few longitudinal studies have examined the ASD's impact upon BD illness course. The current study examined the longitudinal impact of ASD upon bipolar depressive recurrence/recovery. Outpatients referred to the Stanford BD Clinic during 2000-2011 were assessed with the Systematic Treatment Enhancement Program for BD (STEP-BD) Affective Disorders Evaluation at baseline, and with the Clinical Monitoring Form at monthly follow-ups for up to two years of naturalistic treatment. Prevalence and clinical correlates of ASD in 93 recovered (euthymic ≥8 weeks) and 153 depressed BD patients were assessed. Kaplan-Meier analyses (Log-Rank tests) assessed relationships between baseline ASD and longitudinal depressive severity, with Cox Proportional Hazard analyses assessing potential mediators. ASD was only half as common among recovered versus depressed BD outpatients, but was significantly associated with hastened depressive recurrence (Log-Rank p=0.007), mediated by lifetime anxiety disorder and attenuated by lifetime history of psychosis, and had only a non-significant tendency towards association with delayed depre...Continue Reading

Citations

Jun 6, 2018·Psychiatry and Clinical Neurosciences·Yoshikazu Takaesu
Aug 6, 2019·Frontiers in Psychiatry·Luca SteardoPasquale De Fazio
Jun 17, 2020·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Bodil EkholmMats Adler
Oct 30, 2020·The Australian and New Zealand Journal of Psychiatry·Yuichi EsakiTsuyoshi Kitajima
Jan 2, 2021·Journal of Psychiatric Research·B EtainUNKNOWN FACE-BD Clinical Sites and Principal Collaborators in France
Sep 2, 2018·Journal of Affective Disorders·Christopher N KaufmannTerence A Ketter

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