Abnormal Sleep Spindles, Memory Consolidation, and Schizophrenia

Annual Review of Clinical Psychology
Dara S Manoach, Robert Stickgold

Abstract

There is overwhelming evidence that sleep is crucial for memory consolidation. Patients with schizophrenia and their unaffected relatives have a specific deficit in sleep spindles, a defining oscillation of non-rapid eye movement (NREM) Stage 2 sleep that, in coordination with other NREM oscillations, mediate memory consolidation. In schizophrenia, the spindle deficit correlates with impaired sleep-dependent memory consolidation, positive symptoms, and abnormal thalamocortical connectivity. These relations point to dysfunction of the thalamic reticular nucleus (TRN), which generates spindles, gates the relay of sensory information to the cortex, and modulates thalamocortical communication. Genetic studies are beginning to provide clues to possible neurodevelopmental origins of TRN-mediated thalamocortical circuit dysfunction and to identify novel targets for treating the related memory deficits and symptoms. By forging empirical links in causal chains from risk genes to thalamocortical circuit dysfunction, spindle deficits, memory impairment, symptoms, and diagnosis, future research can advance our mechanistic understanding, treatment, and prevention of schizophrenia.

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Citations

Dec 21, 2019·Journal of Sleep Research·Dimitrios MylonasDara S Manoach
Oct 2, 2020·Anesthesiology·Shubham ChamadiaOluwaseun Akeju
Jul 8, 2020·Nature Communications·Laura BojarskaiteErlend A Nagelhus
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Sep 13, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Dimitrios MylonasDara S Manoach
Aug 2, 2020·Neuroscience and Biobehavioral Reviews·Caroline ZanganiArmando D'Agostino
Jun 23, 2020·Sleep Medicine·Philip M Becker
May 2, 2020·Schizophrenia Research·Flavio Fröhlich, Caroline Lustenberger
Sep 21, 2019·Journal of Affective Disorders·Jessica M MeersCandice A Alfano
Jun 16, 2021·Consciousness and Cognition·Tim Julian MöllerLaura Kaltwasser
Aug 12, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Jin-Bo SunWei Qin
Aug 5, 2021·Molecular Autism·Vidya SaravanapandianShafali S Jeste

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