Abnormal Spontaneous Brain Activity in Early Parkinson's Disease With Mild Cognitive Impairment: A Resting-State fMRI Study

Frontiers in Physiology
Zhijiang WangHuali Wang

Abstract

Mild cognitive impairment (MCI) is a common symptom at the baseline of early Parkinson's disease (PD) diagnosis, but the neural mechanism is unclear. To address the issue, the present study employed resting-state functional magnetic resonance imaging data of 19 drug-naïve PD patients with normal cognition (PD-NC), 10 PD patients with MCI (PD-MCI) and 13 age- and gender-matched healthy controls (HC) from the Parkinson's progression markers initiative (PPMI) (http://www.ppmi-info.org/), and examined abnormal spontaneous brain activities in the PD-MCI. The pattern of spontaneous brain activity was measured by examining the amplitude of low-frequency fluctuations (ALFF) of blood oxygen level dependent signal. Voxel-wise one-way analysis of covariance and post hoc analyses of ALFF were performed under non-parametric permutation tests in a general linear model among the three groups, with age, gender and data center as additional covariates. Statistical significances in the post hoc analysis were corrected by a small volume correction with a cluster-level threshold of p < 0.05 (n = 10000 permutations, FWE-corrected). Correlations of clinical and neuropsychological assessments [i.e., Unified Parkinson's Disease Rating Scale (UPDRS) to...Continue Reading

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Citations

Nov 16, 2019·CNS Neuroscience & Therapeutics·Bo ShenLi Zhang
Mar 21, 2020·Journal of Computer Assisted Tomography·Xuewen FengJingzheng Fan
Aug 28, 2020·Frontiers in Neuroscience·Hai-Hua SunChun-Feng Liu
Nov 30, 2019·Frontiers in Aging Neuroscience·Davide Maria CammisuliCarlo Pruneti
Oct 13, 2020·Frontiers in Neurology·Ran WangXiao-Ming Zhang
Mar 18, 2021·Parkinsonism & Related Disorders·Kevin P NguyenAlbert A Montillo
Feb 10, 2021·Harvard Review of Psychiatry·Alan A Baumeister
Dec 7, 2021·Frontiers in Aging Neuroscience·Song'an ShangXindao Yin

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Software Mentioned

Statistical non - Parametric Mapping SnPM13
Statistical Parametric Mapping ( SPM12 )
DPARSF
ALFF
Data Processing Assistant for R - fMRI ( DPARSF )

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