Abstract
Eph receptors and ephrins are involved in establishing topographic connectivity in primary sensory brain regions, but also in higher order structures including the cortex and hippocampus. Ephrin-A2(-/-) mice have abnormal topography in the primary visual system but have normal visual and learning performance on a simple visual discrimination task. Here we use signal detection theory to analyse learning behaviour of these mice. Wild-type (WT) and ephrin-A2(-/-) (KO) mice performed equally well in a two-stimulus visual discrimination task, with similar learning rates and response latencies. However, during reversal learning, when the rewarded stimulus was switched, the two genotypes exhibited differences in response strategies: while WTs favoured a win-stay strategy, KOs remained relatively neutral. KOs also exhibited a stronger lateralization bias in the initial stages of learning, choosing the same arm of the maze with high probability. In addition, use of a Bayesian "optimal observer" revealed that compared to WT, KO mice adapted their decisions less rapidly to a change in stimulus-reward relationship. We suggest that the misexpression of ephrin-A2 may lead to abnormal connectivity in regions known for their involvement in rev...Continue Reading
References
Jan 1, 1985·Psychopharmacology·A Sahgal, G H Clincke
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·P P GaoR Zhou
Nov 5, 1999·Trends in Neurosciences·G J Goodhill, L J Richards
Apr 25, 2000·Neuron·D A FeldheimJ G Flanagan
Mar 22, 2002·NeuroImage·Martin P PaulusGregory G Brown
Mar 22, 2003·Science·Klas KullanderOle Kiehn
Jul 19, 2005·Annual Review of Neuroscience·Todd McLaughlin, Dennis D M O'Leary
Aug 6, 2005·Hearing Research·Karina S Cramer
Mar 3, 2006·Development·Tadashi NomuraNoriko Osumi
May 4, 2006·Psychopharmacology·Stan B Floresco, Orsolya Magyar
Sep 12, 2006·Cerebral Cortex·Annie E BlockStan B Floresco
Oct 4, 2006·Psychopharmacology·Daiki MasakiKenji Fukui
Apr 28, 2007·Trends in Neurosciences·Jean-Philippe Thivierge, Gary F Marcus
Apr 17, 2008·Science Signaling·Martin Lackmann, Andrew W Boyd
May 3, 2008·Neuroscience Letters·Katerina V SavelievaThomas H Lanthorn
Oct 31, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gregory B BissonetteElizabeth M Powell
Dec 30, 2008·Neuroscience and Biobehavioral Reviews·Andrew Holmes, Cara L Wellman
Mar 6, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Desirae M Haluk, Stan B Floresco
Jun 2, 2009·Current Opinion in Neurobiology·Thomas R Clandinin, David A Feldheim
Citations
Jan 26, 2012·Cerebral Cortex·Leann H BrennamanPatricia F Maness
Nov 13, 2012·PloS One·Kalina MakowieckiJennifer Rodger
Sep 7, 2014·Neurobiology of Disease·Moustapha Cissé, Frédéric Checler
Oct 5, 2014·Behavioural Brain Research·Rachel WurzmanLawrence F Kromer
Jan 1, 2013·F1000Research·Matthew SykesJennifer Rodger
Jan 1, 2013·F1000Research·Matthew SykesJennifer Rodger
Jan 29, 2017·Animal Cognition·Pizza Ka Yee ChowStephen E G Lea
Nov 13, 2020·Behavioural Brain Research·Jessica MorettiJennifer Rodger
Feb 2, 2021·Frontiers in Cellular Neuroscience·Tanya Gandhi, Charles C Lee