Abnormal synaptic transmission in the olfactory bulb of Fyn-kinase-deficient mice

Journal of Neurophysiology
H KitazawaN Kawai

Abstract

We studied synaptic transmission in the granule cells in the olfactory bulb of the homozygous Fyn (a nonreceptor type tyrosine kinase)-deficient (fynz/fynz) and heterozygous Fyn-deficient (+/fynz) mice by using slice preparations from the olfactory bulb. Stimulation to the lateral olfactory tract and/or centrifugal fibers to the olfactory bulb evoked field excitatory postsynaptic potentials (fEPSPs) in the granule cells. In +/fynz mice, fEPSPs were augmented by bicuculline, a gamma-aminobutyric acid (GABAA) antagonist and picrotoxin, whereas fEPSPs in fynz/fynz mice were much less sensitive to bicuculline and picrotoxin. Application of D-2-amino-5-phosphonopentanoic acid had no effect but 6-cyano-7-nitroquinoxaline-2,3-dione produced almost complete block of fEPSPs in both +/fynz mice and fynz/fynz mice. (1S,3R)-1-aminocyclo-pentane-1.3-dicarboxylate, an agonist of metabotropic glutamate receptors caused a similar depression of fEPSPs in both +/fynz and fynz/fynz mice. In +/fynz mice tetanic stimulation to the lateral olfactory tract and/or centrifugal fibers induced N-methyl-D-aspartate (NMDA)-dependent long-term potentiation (LTP) of fEPSPs, whereas LTP was impaired in fynz/fynz mice. Our results demonstrate altered functions...Continue Reading

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Citations

Jul 25, 2003·Alcoholism, Clinical and Experimental Research·Stephen L BoehmYuri A Blednov
Dec 7, 2013·PloS One·Sean P Farris, Michael F Miles
Nov 5, 2014·Frontiers in Cell and Developmental Biology·Katharina Ochs, Edward Málaga-Trillo
Feb 7, 2004·The Journal of Pharmacology and Experimental Therapeutics·Stephen L BoehmYuri A Blednov
May 5, 2009·Nature Neuroscience·Antoine NissantPierre-Marie Lledo
Jul 13, 2004·Pharmacology & Therapeutics·Bernhard Lüscher, Cheryl A Keller

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